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Gpbar1 G protein-coupled bile acid receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 227289, updated on 21-Apr-2024

Summary

Official Symbol
Gpbar1provided by MGI
Official Full Name
G protein-coupled bile acid receptor 1provided by MGI
Primary source
MGI:MGI:2653863
See related
Ensembl:ENSMUSG00000064272 AllianceGenome:MGI:2653863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BG37; GPCR; TGR5; M-BAR; GPR131
Summary
Predicted to enable G protein-coupled bile acid receptor activity. Involved in regulation of bicellular tight junction assembly. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of receptor complex. Is expressed in gut and male reproductive gland or organ. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
1 C3; 1 38.53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74316269..74318868)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74278600..74279589)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31691 Neighboring gene predicted gene, 25524 Neighboring gene STARR-positive B cell enhancer ABC_E1996 Neighboring gene actin related protein 2/3 complex, subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E175 Neighboring gene predicted gene 28364 Neighboring gene angio-associated migratory protein Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene paroxysmal nonkinesiogenic dyskinesia

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled bile acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled bile acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables bile acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G-protein coupled bile acid receptor 1
Names
G protein-coupled receptor TGR5
membrane bile acid receptor
membrane-type receptor for bile acids

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174985.2NP_778150.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_778150.1

    Status: VALIDATED

    Source sequence(s)
    AC113473
    Consensus CDS
    CCDS15042.1
    UniProtKB/Swiss-Prot
    Q80SS6
    UniProtKB/TrEMBL
    Q14AA9
    Related
    ENSMUSP00000077135.4, ENSMUST00000077985.4
    Conserved Domains (1) summary
    pfam00001
    Location:108249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74316269..74318868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)