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Plcl1 phospholipase C-like 1 [ Mus musculus (house mouse) ]

Gene ID: 227120, updated on 8-Feb-2024

Summary

Official Symbol
Plcl1provided by MGI
Official Full Name
phospholipase C-like 1provided by MGI
Primary source
MGI:MGI:3036262
See related
Ensembl:ENSMUSG00000038349 AllianceGenome:MGI:3036262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLCE; PLCL; PRIP; PLC-L; PLDL1; PLC-L1; PRIP-1; C230017K02Rik
Summary
Predicted to enable GABA receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including gamma-aminobutyric acid signaling pathway; regulation of GABAergic synaptic transmission; and regulation of peptidyl-serine phosphorylation. Located in plasma membrane. Is expressed in nervous system and vibrissa. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 3.1), cerebellum adult (RPKM 3.0) and 24 other tissues See more
Orthologs
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Genomic context

See Plcl1 in Genome Data Viewer
Location:
1 C1.2; 1 28.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55442722..55793444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55405946..55754285)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene boule homolog, RNA binding protein Neighboring gene STARR-seq mESC enhancer starr_00957 Neighboring gene predicted gene 8292 Neighboring gene basic transcription factor 3, pseudogene 17 Neighboring gene STARR-positive B cell enhancer mm9_chr1:55461214-55461515 Neighboring gene predicted gene 8531 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:55503167-55503392 Neighboring gene STARR-seq mESC enhancer starr_00958 Neighboring gene STARR-seq mESC enhancer starr_00959 Neighboring gene Akr1b3 pseudogene Neighboring gene predicted gene, 39642 Neighboring gene STARR-seq mESC enhancer starr_00961 Neighboring gene STARR-seq mESC enhancer starr_00962 Neighboring gene RIKEN cDNA 9130227L01 gene Neighboring gene predicted gene, 32949

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1092

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GABA receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive phospholipase C-like protein 1
Names
phospholipase C, eta 2 pseudogene
phospholipase C-related but catalytically inactive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114663.1NP_001108135.1  inactive phospholipase C-like protein 1

    See identical proteins and their annotated locations for NP_001108135.1

    Status: PROVISIONAL

    Source sequence(s)
    AC145691, AI644888, AK083136, AK140530, BE981359
    Consensus CDS
    CCDS48263.1
    UniProtKB/Swiss-Prot
    D3Z0W5, Q3TSM9, Q3USB7
    Related
    ENSMUSP00000037854.9, ENSMUST00000042986.10
    Conserved Domains (5) summary
    cd00275
    Location:721849
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:399689
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:116224
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:244273
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:244386
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    55442722..55793444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164399.1XP_036020292.1  inactive phospholipase C-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd00275
    Location:721849
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:399689
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:116224
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16222
    Location:244386
    EFh_PRIP1; EF-hand motif found in phospholipase C-related but catalytically inactive protein 1 (PRIP-1)

RNA

  1. XR_004941953.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_018587.1: Suppressed sequence

    Description
    NG_018587.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.