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Taf5 TATA-box binding protein associated factor 5 [ Mus musculus (house mouse) ]

Gene ID: 226182, updated on 8-Dec-2022

Summary

Official Symbol
Taf5provided by MGI
Official Full Name
TATA-box binding protein associated factor 5provided by MGI
Primary source
MGI:MGI:2442144
See related
Ensembl:ENSMUSG00000025049 AllianceGenome:MGI:2442144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330528C20Rik
Summary
Enables DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in embryo and tail. Orthologous to human TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 3.8), CNS E11.5 (RPKM 3.7) and 28 other tissues See more
Orthologs
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Genomic context

See Taf5 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47056187..47071918)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47067748..47083479)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 6 Neighboring gene predicted gene, 23140 Neighboring gene ATP synthase membrane subunit DAPIT Neighboring gene programmed cell death 11 Neighboring gene calcium homeostasis modulator family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 5
Names
TAF(II)100
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAFII-100
TAFII100
Tbp-associated factor 5
transcription initiation factor TFIID 100 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177342.3NP_796316.2  transcription initiation factor TFIID subunit 5

    See identical proteins and their annotated locations for NP_796316.2

    Status: VALIDATED

    Source sequence(s)
    AC124724, AK031985, BQ714348, BU057827
    Consensus CDS
    CCDS29886.1
    UniProtKB/Swiss-Prot
    Q8C092
    UniProtKB/TrEMBL
    F8VPY2
    Related
    ENSMUSP00000026027.6, ENSMUST00000026027.7
    Conserved Domains (4) summary
    cd08044
    Location:212344
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    COG2319
    Location:460741
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:473743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:474542
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47056187..47071918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)