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Xpa xeroderma pigmentosum, complementation group A [ Mus musculus (house mouse) ]

Gene ID: 22590, updated on 5-Apr-2024

Summary

Official Symbol
Xpaprovided by MGI
Official Full Name
xeroderma pigmentosum, complementation group Aprovided by MGI
Primary source
MGI:MGI:99135
See related
Ensembl:ENSMUSG00000028329 AllianceGenome:MGI:99135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xpac
Summary
Predicted to enable DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; nucleotide-excision repair; and positive regulation of transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in forelimb bud. Used to study xeroderma pigmentosum group A. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.5), duodenum adult (RPKM 8.1) and 28 other tissues See more
Orthologs
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Genomic context

See Xpa in Genome Data Viewer
Location:
4 B1; 4 24.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46175222..46196317, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46175220..46196344, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tropomodulin 1 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 Neighboring gene nuclear cap binding protein subunit 1 Neighboring gene STARR-seq mESC enhancer starr_10120 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:46209123-46209232 Neighboring gene predicted gene, 31617 Neighboring gene predicted gene 12444

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in UV protection ISO
Inferred from Sequence Orthology
more info
 
involved_in UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair, DNA damage recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription initiation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-excision repair factor 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA repair protein complementing XP-A cells homolog
Names
xeroderma pigmentosum group A-complementing protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424855.1NP_001411784.1  DNA repair protein complementing XP-A cells homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL806523
  2. NM_001424856.1NP_001411785.1  DNA repair protein complementing XP-A cells homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL806523
  3. NM_001424857.1NP_001411786.1  DNA repair protein complementing XP-A cells homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL806523
  4. NM_011728.3NP_035858.2  DNA repair protein complementing XP-A cells homolog isoform 1

    See identical proteins and their annotated locations for NP_035858.2

    Status: VALIDATED

    Source sequence(s)
    AL806523
    Consensus CDS
    CCDS18146.1
    UniProtKB/Swiss-Prot
    A2ALZ7, Q64267, Q9CVA0
    Related
    ENSMUSP00000030013.6, ENSMUST00000030013.12
    Conserved Domains (3) summary
    TIGR00598
    Location:104272
    rad14; DNA repair protein
    pfam01286
    Location:103132
    XPA_N; XPA protein N-terminal
    pfam05181
    Location:134185
    XPA_C; XPA protein C-terminus

RNA

  1. NR_188966.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL806523
  2. NR_188967.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL806523
  3. NR_188968.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL806523
  4. NR_188969.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL806523
  5. NR_188970.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL806523
  6. NR_188971.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL806523

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46175222..46196317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)