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Etf1 eukaryotic translation termination factor 1 [ Mus musculus (house mouse) ]

Gene ID: 225363, updated on 8-Dec-2022

Summary

Official Symbol
Etf1provided by MGI
Official Full Name
eukaryotic translation termination factor 1provided by MGI
Primary source
MGI:MGI:2385071
See related
Ensembl:ENSMUSG00000024360 AllianceGenome:MGI:2385071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERF; ERF1; TB3-1; SUP45L1; D6Ertd109e
Summary
Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation and translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in central nervous system and retina. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 27.4), CNS E11.5 (RPKM 25.7) and 28 other tissues See more
Orthologs
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Genomic context

See Etf1 in Genome Data Viewer
Location:
18; 18 B1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35035838..35065060, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34902785..34932008, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene early growth response 1 Neighboring gene predicted gene, 54018 Neighboring gene heat shock protein 9 Neighboring gene predicted gene, 22200 Neighboring gene predicted gene, 26109

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18745

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sequence-specific mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
 
enables translation release factor activity, codon specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation termination factor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of translation release factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic peptide chain release factor subunit 1
Names
eukaryotic release factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144866.3NP_659115.3  eukaryotic peptide chain release factor subunit 1

    See identical proteins and their annotated locations for NP_659115.3

    Status: VALIDATED

    Source sequence(s)
    AC114820, AI844751, AK169345, BY238984
    Consensus CDS
    CCDS29137.1
    UniProtKB/Swiss-Prot
    Q8BWY3, Q91VH9
    UniProtKB/TrEMBL
    A0A6P5NVP0, A0A8C6GVU6, Q3TF02
    Related
    ENSMUSP00000025218.8, ENSMUST00000025218.8
    Conserved Domains (1) summary
    COG1503
    Location:11419
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35035838..35065060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250436.2XP_030106296.1  eukaryotic peptide chain release factor subunit 1 isoform X1

    Conserved Domains (1) summary
    COG1503
    Location:1386
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]