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FGF8 fibroblast growth factor 8 [ Homo sapiens (human) ]

Gene ID: 2253, updated on 22-May-2020

Summary

Official Symbol
FGF8provided by HGNC
Official Full Name
fibroblast growth factor 8provided by HGNC
Primary source
HGNC:HGNC:3686
See related
Ensembl:ENSG00000107831 MIM:600483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH6; AIGF; KAL6; FGF-8; HBGF-8
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See FGF8 in Genome Data Viewer
Location:
10q24.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101770130..101780369, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103529887..103540126, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378458 Neighboring gene uncharacterized LOC105378457 Neighboring gene VISTA enhancer hs511 Neighboring gene FGF8 5' regulatory region Neighboring gene VISTA enhancer hs513 Neighboring gene nucleophosmin/nucleoplasmin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
anatomical structure morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in mesendoderm migration IEA
Inferred from Electronic Annotation
more info
 
cell proliferation in forebrain IEA
Inferred from Electronic Annotation
more info
 
corticotropin hormone secreting cell differentiation IEA
Inferred from Electronic Annotation
more info
 
dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
dorsal/ventral axon guidance IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic neurocranium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition involved in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
forebrain dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
forebrain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
forebrain neuron development IEA
Inferred from Electronic Annotation
more info
 
gastrulation NAS
Non-traceable Author Statement
more info
PubMed 
gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IEA
Inferred from Electronic Annotation
more info
 
lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell migration IEA
Inferred from Electronic Annotation
more info
 
mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
midbrain-hindbrain boundary development IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neural plate morphogenesis IEA
Inferred from Electronic Annotation
more info
 
neuroepithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
organ induction IEA
Inferred from Electronic Annotation
more info
 
otic vesicle formation IEA
Inferred from Electronic Annotation
more info
 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
pallium development IEA
Inferred from Electronic Annotation
more info
 
pharyngeal system development IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
regulation of odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
subpallium development IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
thyroid-stimulating hormone-secreting cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fibroblast growth factor 8
Names
androgen-induced growth factor
fibroblast growth factor 8 (androgen-induced)
heparin-binding growth factor 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007151.1 RefSeqGene

    Range
    4957..10940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206389.2NP_001193318.1  fibroblast growth factor 8 isoform G

    See identical proteins and their annotated locations for NP_001193318.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (G) has an alternate 5' exon and lacks an internal segment in the 5' region, compared to variant F. The encoded isoform (G) is shorter at the N-terminus, compared to isoform F.
    Source sequence(s)
    AC010789, CN369230
    Consensus CDS
    CCDS73185.1
    UniProtKB/TrEMBL
    A0A087X1S5
    Related
    ENSP00000484420.1, ENST00000618991.4
    Conserved Domains (1) summary
    pfam00167
    Location:1100
    FGF; Fibroblast growth factor
  2. NM_006119.6NP_006110.1  fibroblast growth factor 8 isoform B precursor

    See identical proteins and their annotated locations for NP_006110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (B) is shorter than isoform F.
    Source sequence(s)
    AC010789, BC128236, U36223
    Consensus CDS
    CCDS7515.1
    UniProtKB/Swiss-Prot
    P55075
    UniProtKB/TrEMBL
    A1A515
    Related
    ENSP00000321945.2, ENST00000347978.2
    Conserved Domains (1) summary
    pfam00167
    Location:52175
    FGF; Fibroblast growth factor
  3. NM_033163.5NP_149353.1  fibroblast growth factor 8 isoform F precursor

    See identical proteins and their annotated locations for NP_149353.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) encodes the longest isoform (F).
    Source sequence(s)
    AC010789, BC069106, BC128236
    Consensus CDS
    CCDS7516.1
    UniProtKB/Swiss-Prot
    P55075
    UniProtKB/TrEMBL
    A1A515
    Related
    ENSP00000321797.2, ENST00000320185.6
    Conserved Domains (1) summary
    pfam00167
    Location:81204
    FGF; Fibroblast growth factor
  4. NM_033164.4NP_149354.1  fibroblast growth factor 8 isoform E precursor

    See identical proteins and their annotated locations for NP_149354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) uses an alternate splice site, compared to variant F. The encoded isoform (E) is shorter than isoform F.
    Source sequence(s)
    AC010789, BC128236, U46213
    Consensus CDS
    CCDS7517.1
    UniProtKB/Swiss-Prot
    P55075
    UniProtKB/TrEMBL
    A1A515
    Related
    ENSP00000340039.3, ENST00000344255.8
    Conserved Domains (1) summary
    pfam00167
    Location:70193
    FGF; Fibroblast growth factor
  5. NM_033165.5NP_149355.1  fibroblast growth factor 8 isoform A precursor

    See identical proteins and their annotated locations for NP_149355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks an in-frame exon and uses an alternate splice site, compared to variant F. The encoded isoform (A) is shorter than isoform F.
    Source sequence(s)
    AC010789, BC128236
    Consensus CDS
    CCDS7518.1
    UniProtKB/Swiss-Prot
    P55075
    UniProtKB/TrEMBL
    A1A515
    Related
    ENSP00000344306.3, ENST00000346714.7
    Conserved Domains (1) summary
    pfam00167
    Location:41164
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101770130..101780369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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