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Srsf7 serine/arginine-rich splicing factor 7 [ Mus musculus (house mouse) ]

Gene ID: 225027, updated on 8-Jun-2019

Summary

Official Symbol
Srsf7provided by MGI
Official Full Name
serine/arginine-rich splicing factor 7provided by MGI
Primary source
MGI:MGI:1926232
See related
Ensembl:ENSMUSG00000024097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9G8; 35kDa; NX-96; Sfrs7; 9430065L19Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Five transcript variants, four of them protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Broad expression in CNS E11.5 (RPKM 98.8), CNS E14 (RPKM 77.4) and 22 other tissues See more
Orthologs

Genomic context

See Srsf7 in Genome Data Viewer
Location:
17; 17 E3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (80200080..80207317, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (80599420..80606625, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41626 Neighboring gene galactose mutarotase Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 Neighboring gene MORN repeat containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC38287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA splicing ISO
Inferred from Sequence Orthology
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 7
Names
splicing factor, arginine/serine-rich 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195485.1NP_001182414.1  serine/arginine-rich splicing factor 7 isoform 2

    See identical proteins and their annotated locations for NP_001182414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK045884, AK082848, AK137795, BX519093
    UniProtKB/Swiss-Prot
    Q8BL97
    UniProtKB/TrEMBL
    Q3THA6
    Related
    ENSMUSP00000157383.1, ENSMUST00000235069.1
    Conserved Domains (1) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
  2. NM_001195486.1NP_001182415.1  serine/arginine-rich splicing factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001182415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK045884, AK137795, BX519093, BY740981
    UniProtKB/Swiss-Prot
    Q8BL97
    UniProtKB/TrEMBL
    Q3THA6
    Conserved Domains (2) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
    pfam00098
    Location:104119
    zf-CCHC; Zinc knuckle
  3. NM_001195487.1NP_001182416.1  serine/arginine-rich splicing factor 7 isoform 4

    See identical proteins and their annotated locations for NP_001182416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI550251, AK045884, AK137795, BX519093
    UniProtKB/Swiss-Prot
    Q8BL97
    UniProtKB/TrEMBL
    Q3THA6
    Conserved Domains (2) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
    pfam00098
    Location:104119
    zf-CCHC; Zinc knuckle
  4. NM_001360435.1NP_001347364.1  serine/arginine-rich splicing factor 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC132910, AC140361
    Conserved Domains (2) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
    pfam00098
    Location:104119
    zf-CCHC; Zinc knuckle
  5. NM_146083.2NP_666195.1  serine/arginine-rich splicing factor 7 isoform 1

    See identical proteins and their annotated locations for NP_666195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK045884, AK137795, BX519093
    Consensus CDS
    CCDS28988.1
    UniProtKB/Swiss-Prot
    Q8BL97
    UniProtKB/TrEMBL
    Q3THA6
    Related
    ENSMUSP00000070983.9, ENSMUST00000063417.10
    Conserved Domains (2) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
    pfam00098
    Location:104119
    zf-CCHC; Zinc knuckle

RNA

  1. NR_036615.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon with an in-frame stop codon. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so this variant is not thought to be protein-coding.
    Source sequence(s)
    AC132910, AK034952, AK045884, BX519093

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    80200080..80207317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246412.2XP_011244714.1  serine/arginine-rich splicing factor 7 isoform X3

  2. XM_011246413.1XP_011244715.1  serine/arginine-rich splicing factor 7 isoform X4

  3. XM_006524191.1XP_006524254.1  serine/arginine-rich splicing factor 7 isoform X2

    See identical proteins and their annotated locations for XP_006524254.1

    Related
    ENSMUSP00000157263.1, ENSMUST00000234696.1
    Conserved Domains (2) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
    pfam00098
    Location:104119
    zf-CCHC; Zinc knuckle
  4. XM_006524190.2XP_006524253.1  serine/arginine-rich splicing factor 7 isoform X1

    UniProtKB/Swiss-Prot
    Q8BL97
    Conserved Domains (2) summary
    cd12646
    Location:1288
    RRM_SRSF7; RNA recognition motif in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)
    pfam00098
    Location:104119
    zf-CCHC; Zinc knuckle

RNA

  1. XR_001782073.1 RNA Sequence

  2. XR_876493.1 RNA Sequence

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