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Ubr2 ubiquitin protein ligase E3 component n-recognin 2 [ Mus musculus (house mouse) ]

Gene ID: 224826, updated on 5-Mar-2024

Summary

Official Symbol
Ubr2provided by MGI
Official Full Name
ubiquitin protein ligase E3 component n-recognin 2provided by MGI
Primary source
MGI:MGI:1861099
See related
Ensembl:ENSMUSG00000023977 AllianceGenome:MGI:1861099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0349; 9930021A08Rik; E130209G04Rik
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including histone H2A ubiquitination; male gamete generation; and negative regulation of transposition. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Colocalizes with chromatin. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 12.1), thymus adult (RPKM 12.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ubr2 in Genome Data Viewer
Location:
17 C; 17 22.91 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47239217..47321812, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46928291..47010886, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene tubulin-specific chaperone C Neighboring gene peripherin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3205 Neighboring gene STARR-positive B cell enhancer ABC_E4216 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene ribosomal protein L29 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0349, MGC36320

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables leucine binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UBR2
Names
N-recognin-2
RING-type E3 ubiquitin transferase UBR2
ubiquitin ligase E3 alpha-II
ubiquitin-protein ligase E3-alpha-2
ubiquitin-protein ligase E3-alpha-II
NP_001170845.1
NP_666190.2
XP_006524208.1
XP_030105595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177374.2NP_001170845.1  E3 ubiquitin-protein ligase UBR2 isoform 2

    See identical proteins and their annotated locations for NP_001170845.1

    Status: VALIDATED

    Source sequence(s)
    AC165289, AC170807
    Consensus CDS
    CCDS50127.1
    UniProtKB/TrEMBL
    Q3UHE0, Q3UPU3
    Related
    ENSMUSP00000108961.3, ENSMUST00000113335.4
    Conserved Domains (2) summary
    pfam02207
    Location:99166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:222300
    ClpS; ATP-dependent Clp protease adaptor protein ClpS
  2. NM_146078.4NP_666190.2  E3 ubiquitin-protein ligase UBR2 isoform 1

    See identical proteins and their annotated locations for NP_666190.2

    Status: VALIDATED

    Source sequence(s)
    AC165289, AC170807
    Consensus CDS
    CCDS28845.1
    UniProtKB/Swiss-Prot
    Q6DIB9, Q6WKZ8, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130
    UniProtKB/TrEMBL
    Q3UHE0
    Related
    ENSMUSP00000108963.3, ENSMUST00000113337.10
    Conserved Domains (2) summary
    pfam02207
    Location:99166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:222300
    ClpS; ATP-dependent Clp protease adaptor protein ClpS

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47239217..47321812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524145.3XP_006524208.1  E3 ubiquitin-protein ligase UBR2 isoform X2

    Conserved Domains (2) summary
    cd00162
    Location:422527
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:421536
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_030249735.2XP_030105595.1  E3 ubiquitin-protein ligase UBR2 isoform X1

    Conserved Domains (2) summary
    cd00162
    Location:679784
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:678793
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_001782069.3 RNA Sequence