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Lemd2 LEM domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 224640, updated on 29-Jan-2023


Official Symbol
Lemd2provided by MGI
Official Full Name
LEM domain containing 2provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000044857 AllianceGenome:MGI:2385045
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lem2; NET25
Predicted to enable chromatin DNA binding activity. Involved in heart formation; negative regulation of protein kinase B signaling; and neurogenesis. Acts upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Located in nuclear membrane. Is expressed in several structures, including heart; liver; nephric duct; neural tube; and tibialis anterior. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in adrenal adult (RPKM 61.9), ovary adult (RPKM 61.0) and 28 other tissues See more
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Genomic context

See Lemd2 in Genome Data Viewer
17; 17 A3.3
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27408574..27426228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27189600..27205470, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 Neighboring gene inositol hexaphosphate kinase 3 Neighboring gene predicted gene, 34736 Neighboring gene RIKEN cDNA 9630028I04 gene Neighboring gene microRNA 7214

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • MGC37253

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
colocalizes_with chromatin ISO
Inferred from Sequence Orthology
more info
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
colocalizes_with nuclear envelope ISO
Inferred from Sequence Orthology
more info
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
located_in nucleus IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
LEM domain-containing protein 2
nuclear envelope constituent
nuclear envelope transmembrane protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146075.2NP_666187.2  LEM domain-containing protein 2

    See identical proteins and their annotated locations for NP_666187.2

    Status: VALIDATED

    Source sequence(s)
    AA259360, AK082131, AK143224, BY732449
    Consensus CDS
    Q6DVA0, Q8R0N2
    ENSMUSP00000058221.8, ENSMUST00000055117.9
    Conserved Domains (2) summary
    MSC; Man1-Src1p-C-terminal domain
    LEM; LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000083.7 Reference GRCm39 C57BL/6J

    27408574..27426228 complement
    GenBank, FASTA, Sequence Viewer (Graphics)


  1. XR_876473.4 RNA Sequence

  2. XR_876472.4 RNA Sequence