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Acat3 acetyl-Coenzyme A acetyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 224530, updated on 6-Jun-2024

Summary

Official Symbol
Acat3provided by MGI
Official Full Name
acetyl-Coenzyme A acetyltransferase 3provided by MGI
Primary source
MGI:MGI:109182
See related
Ensembl:ENSMUSG00000062480 AllianceGenome:MGI:109182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACTL
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including liver; lung; metanephros; nervous system; and neural retina. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 88.4), CNS E11.5 (RPKM 44.2) and 28 other tissues See more
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Genomic context

See Acat3 in Genome Data Viewer
Location:
17 A1; 17 8.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13142720..13159482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12923830..12940595, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex protein 1 Neighboring gene predicted gene, 26130 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetyl-CoA C-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
acetyl-Coenzyme A acetyltransferase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410277.1NP_001397206.1  acetyl-Coenzyme A acetyltransferase 3

    Status: VALIDATED

    Source sequence(s)
    AL589878
    UniProtKB/TrEMBL
    F2Z459, Q80X81, Q8R4V3
    Related
    ENSMUSP00000125454.3, ENSMUST00000160378.3
  2. NM_153151.4NP_694791.2  acetyl-Coenzyme A acetyltransferase 3

    See identical proteins and their annotated locations for NP_694791.2

    Status: VALIDATED

    Source sequence(s)
    AL589878
    Consensus CDS
    CCDS28398.1
    UniProtKB/TrEMBL
    F2Z459, Q80X81, Q8R4V3
    Related
    ENSMUSP00000045912.6, ENSMUST00000043923.12
    Conserved Domains (1) summary
    PRK05790
    Location:8396
    PRK05790; putative acyltransferase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13142720..13159482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)