Format

Send to:

Choose Destination

FGA fibrinogen alpha chain [ Homo sapiens (human) ]

Gene ID: 2243, updated on 23-Nov-2021

Summary

Official Symbol
FGAprovided by HGNC
Official Full Name
fibrinogen alpha chainprovided by HGNC
Primary source
HGNC:HGNC:3661
See related
Ensembl:ENSG00000171560 MIM:134820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fib2
Summary
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward liver (RPKM 2863.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FGA in Genome Data Viewer
Location:
4q31.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (154583126..154590742, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (155504278..155511894, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene fibrinogen beta chain Neighboring gene fibrinogen gamma chain Neighboring gene VISTA enhancer hs1706

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Afibrinogenemia, congenital
MedGen: C2584774 OMIM: 202400 GeneReviews: Not available
Compare labs
Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.
GeneReviews: Not available
Dysfibrinogenemia, congenital
MedGen: C0272350 OMIM: 616004 GeneReviews: Not available
Compare labs
Familial visceral amyloidosis, Ostertag type
MedGen: C0268389 OMIM: 105200 GeneReviews: Not available
Compare labs
Genetic predictors of fibrin D-dimer levels in healthy adults.
GeneReviews: Not available
Genetics of venous thrombosis: insights from a new genome wide association study.
GeneReviews: Not available
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119422, MGC119423, MGC119425

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation, common pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood coagulation, common pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood coagulation, fibrin clot formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibrinolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fibrinolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in induction of bacterial agglutination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet aggregation HMP PubMed 
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptide hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptide hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibrinogen alpha chain
Names
fibrinogen, A alpha polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008832.1 RefSeqGene

    Range
    5001..12618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_557

mRNA and Protein(s)

  1. NM_000508.5NP_000499.1  fibrinogen alpha chain isoform alpha-E preproprotein

    See identical proteins and their annotated locations for NP_000499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha-E) represents the longer transcript and encodes the longer isoform (alpha-E).
    Source sequence(s)
    AC107385, AF090936, BG565064, BQ064506, BX494953
    Consensus CDS
    CCDS3787.1
    UniProtKB/Swiss-Prot
    P02671
    Related
    ENSP00000498441.1, ENST00000651975.1
    Conserved Domains (3) summary
    cd00087
    Location:630863
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:50187
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:445509
    Fibrinogen_aC; Fibrinogen alpha C domain
  2. NM_021871.4NP_068657.1  fibrinogen alpha chain isoform alpha precursor

    See identical proteins and their annotated locations for NP_068657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) is alternatively spliced in the 3' coding region and 3' UTR, resulting in a shorter isoform (alpha) with a different carboxy-terminus compared to isoform alpha-E. The encoded isoform (alpha) may undergo proteolytic processing similar to isoform alpha-E.
    Source sequence(s)
    AL531808, AL579998, BX494953, CB122305, CD608675, J00127, J00128
    Consensus CDS
    CCDS47152.1
    UniProtKB/Swiss-Prot
    P02671
    Related
    ENSP00000385981.3, ENST00000403106.8
    Conserved Domains (2) summary
    pfam08702
    Location:50187
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:445509
    Fibrinogen_aC; Fibrinogen alpha C domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    154583126..154590742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center