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FER FER tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2241, updated on 17-Jun-2019

Summary

Official Symbol
FERprovided by HGNC
Official Full Name
FER tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3655
See related
Ensembl:ENSG00000151422 MIM:176942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TYK3; PPP1R74; p94-Fer
Summary
The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.2) and 25 other tissues See more
Orthologs

Genomic context

See FER in Genome Data Viewer
Location:
5q21.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (108746085..109196841)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (108083523..108523373)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986440 Neighboring gene long intergenic non-protein coding RNA 1023 Neighboring gene receptor for activated C kinase 1 pseudogene Neighboring gene LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene RNA, U6 small nuclear 47, pseudogene Neighboring gene gap junction protein alpha 1 pseudogene 1 Neighboring gene uncharacterized LOC285638 Neighboring gene praja ring finger ubiquitin ligase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Novel locus FER is associated with serum HMW adiponectin levels.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11826, FLJ35001, FLJ41853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-epsilon receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Kit signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion mediated by cadherin ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to macrophage colony-stimulating factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
diapedesis ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway via phosphatidylinositol 3-kinase ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mast cell activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
response to platelet-derived growth factor ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase Fer
Names
feline encephalitis virus-related kinase FER
fer (fps/fes related) tyrosine kinase
fujinami poultry sarcoma/Feline sarcoma-related protein Fer
phosphoprotein NCP94
protein phosphatase 1, regulatory subunit 74
proto-oncogene c-Fer
tyrosine kinase 3
NP_001294957.1
NP_001294960.1
NP_001294967.1
NP_005237.2
XP_011541568.1
XP_011541569.1
XP_011541571.1
XP_011541572.1
XP_011541573.1
XP_011541574.1
XP_011541578.1
XP_011541580.1
XP_016864718.1
XP_016864719.1
XP_016864720.1
XP_016864721.1
XP_016864722.1
XP_016864723.1
XP_016864724.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011445.2 RefSeqGene

    Range
    5001..454020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308028.2NP_001294957.1  tyrosine-protein kinase Fer isoform b

    See identical proteins and their annotated locations for NP_001294957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC116428, AK299855, AK315234, AL707447, BQ009328, J03358
    UniProtKB/Swiss-Prot
    P16591
    UniProtKB/TrEMBL
    W0S1B5
    Conserved Domains (4) summary
    cd10361
    Location:278363
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05085
    Location:391641
    PTKc_Fer; Catalytic domain of the Protein Tyrosine Kinase, Fer
    pfam07714
    Location:388639
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:163
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_001308031.1NP_001294960.1  tyrosine-protein kinase Fer isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 5' exons but contains an alternate 5' terminal exon derived from the use of an internal promoter, and it thus differs in the 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c, also known as FerT) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC116428, BQ009328, BU155168, J03358, JQ412173
    Consensus CDS
    CCDS78044.1
    UniProtKB/Swiss-Prot
    P16591
    Related
    ENSP00000484767.1, ENST00000618353.1
    Conserved Domains (3) summary
    cd10361
    Location:84169
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05085
    Location:197447
    PTKc_Fer; Catalytic domain of the Protein Tyrosine Kinase, Fer
    pfam07714
    Location:194445
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001308038.2NP_001294967.1  tyrosine-protein kinase Fer isoform d

    See identical proteins and their annotated locations for NP_001294967.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and lacks several exons in the central and 3' coding regions but instead contains alternate 3' exon structure, thereby differing in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AC008871, AK315234, AL707447, BC058030
    UniProtKB/Swiss-Prot
    P16591
    UniProtKB/TrEMBL
    Q6PEJ9
    Related
    ENSP00000486048.1, ENST00000628534.1
    Conserved Domains (1) summary
    cl12013
    Location:5163
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. NM_005246.4NP_005237.2  tyrosine-protein kinase Fer isoform a

    See identical proteins and their annotated locations for NP_005237.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as p94-Fer or FerS).
    Source sequence(s)
    AC116428, AK315234, BQ009328, J03358
    Consensus CDS
    CCDS4098.1
    UniProtKB/Swiss-Prot
    P16591
    UniProtKB/TrEMBL
    W0S0X4
    Related
    ENSP00000281092.4, ENST00000281092.9
    Conserved Domains (3) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:566816
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_146155.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109481, AC116428, AK315234, AL707447, BQ009328, HY146611, J03358

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    108746085..109196841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543267.2XP_011541569.1  tyrosine-protein kinase Fer isoform X1

    See identical proteins and their annotated locations for XP_011541569.1

    Conserved Domains (4) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:563829
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:566831
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011543269.2XP_011541571.1  tyrosine-protein kinase Fer isoform X1

    See identical proteins and their annotated locations for XP_011541571.1

    Conserved Domains (4) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:563829
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:566831
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017009231.2XP_016864720.1  tyrosine-protein kinase Fer isoform X2

    UniProtKB/Swiss-Prot
    P16591
    UniProtKB/TrEMBL
    W0S0X4
    Conserved Domains (3) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:566816
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011543270.3XP_011541572.1  tyrosine-protein kinase Fer isoform X1

    See identical proteins and their annotated locations for XP_011541572.1

    Conserved Domains (4) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:563829
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:566831
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017009230.2XP_016864719.1  tyrosine-protein kinase Fer isoform X2

    UniProtKB/Swiss-Prot
    P16591
    UniProtKB/TrEMBL
    W0S0X4
    Conserved Domains (3) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:566816
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017009229.2XP_016864718.1  tyrosine-protein kinase Fer isoform X1

    Conserved Domains (4) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:563829
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:566831
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017009232.2XP_016864721.1  tyrosine-protein kinase Fer isoform X3

  8. XM_011543266.2XP_011541568.1  tyrosine-protein kinase Fer isoform X1

    See identical proteins and their annotated locations for XP_011541568.1

    Conserved Domains (4) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:563829
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:566831
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011543271.3XP_011541573.1  tyrosine-protein kinase Fer isoform X2

    See identical proteins and their annotated locations for XP_011541573.1

    UniProtKB/Swiss-Prot
    P16591
    UniProtKB/TrEMBL
    W0S0X4
    Conserved Domains (3) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    cd10361
    Location:453538
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:566816
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011543272.2XP_011541574.1  tyrosine-protein kinase Fer isoform X4

    Conserved Domains (3) summary
    cd07686
    Location:5238
    F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
    pfam07714
    Location:495761
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:498763
    PKc_like; Protein Kinases, catalytic domain
  11. XM_017009234.1XP_016864723.1  tyrosine-protein kinase Fer isoform X6

  12. XM_017009235.1XP_016864724.1  tyrosine-protein kinase Fer isoform X7

  13. XM_011543278.1XP_011541580.1  tyrosine-protein kinase Fer isoform X9

    Conserved Domains (1) summary
    cl12013
    Location:5238
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  14. XM_017009233.2XP_016864722.1  tyrosine-protein kinase Fer isoform X5

    Conserved Domains (4) summary
    cd10361
    Location:380465
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:490756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:1165
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21453
    Location:493758
    PKc_like; Protein Kinases, catalytic domain
  15. XM_011543276.2XP_011541578.1  tyrosine-protein kinase Fer isoform X8

    Conserved Domains (3) summary
    cd10361
    Location:84169
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:194460
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:197462
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_948244.2 RNA Sequence

  2. XR_001742041.1 RNA Sequence

  3. XR_002956153.1 RNA Sequence

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