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Wdr1 WD repeat domain 1 [ Mus musculus (house mouse) ]

Gene ID: 22388, updated on 21-Apr-2024

Summary

Official Symbol
Wdr1provided by MGI
Official Full Name
WD repeat domain 1provided by MGI
Primary source
MGI:MGI:1337100
See related
Ensembl:ENSMUSG00000005103 AllianceGenome:MGI:1337100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aip1; rede; D5Wsu185e
Summary
Predicted to enable actin filament binding activity. Involved in several processes, including cytoskeleton organization; establishment of planar polarity of follicular epithelium; and platelet formation. Acts upstream of or within positive regulation of actin filament depolymerization; regulation of ventricular cardiac muscle cell membrane repolarization; and sarcomere organization. Located in myelin sheath. Is expressed in several structures, including genitourinary system; heart; pharynx mesenchyme; telencephalon; and trunk mesenchyme. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 105.0), bladder adult (RPKM 95.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 B3; 5 20.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38684149..38720265, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38526806..38562922, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm253 Neighboring gene predicted gene 15796 Neighboring gene predicted gene, 54329 Neighboring gene predicted gene, 22249 Neighboring gene STARR-positive B cell enhancer ABC_E6325 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_12921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:39023837-39024020 Neighboring gene STARR-seq mESC enhancer starr_12923 Neighboring gene STARR-seq mESC enhancer starr_12924 Neighboring gene zinc finger protein 518B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament fragmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apical junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of planar polarity of follicular epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in maintenance of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of actin filament depolymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 1
Names
WD40 repeat protein 1
actin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011715.3NP_035845.1  WD repeat-containing protein 1

    See identical proteins and their annotated locations for NP_035845.1

    Status: VALIDATED

    Source sequence(s)
    AC084322, AC171271
    Consensus CDS
    CCDS51485.1
    UniProtKB/Swiss-Prot
    O88342
    UniProtKB/TrEMBL
    Q3TJY2, Q9DBM8, Q9DC08
    Related
    ENSMUSP00000005234.10, ENSMUST00000005234.13
    Conserved Domains (4) summary
    COG2319
    Location:53475
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:54389
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:62100
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:312602
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38684149..38720265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503863.5XP_006503926.1  WD repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TE06
    Conserved Domains (3) summary
    cd00200
    Location:54389
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:62100
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:312521
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...