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Pim3 proviral integration site 3 [ Mus musculus (house mouse) ]

Gene ID: 223775, updated on 8-Feb-2024

Summary

Official Symbol
Pim3provided by MGI
Official Full Name
proviral integration site 3provided by MGI
Primary source
MGI:MGI:1355297
See related
Ensembl:ENSMUSG00000035828 AllianceGenome:MGI:1355297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kid1
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in spleen. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 73.4), duodenum adult (RPKM 37.2) and 26 other tissues See more
Orthologs
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Genomic context

See Pim3 in Genome Data Viewer
Location:
15 E3; 15 44.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88746397..88749929)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (88862194..88865726)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene predicted gene, 23144 Neighboring gene STARR-positive B cell enhancer ABC_E4145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:88692779-88692962 Neighboring gene predicted gene, 33049 Neighboring gene STARR-seq mESC enhancer starr_39448 Neighboring gene predicted gene, 38643 Neighboring gene tubulin tyrosine ligase-like family, member 8 Neighboring gene STARR-seq mESC enhancer starr_39454 Neighboring gene megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC27707, MGC37517

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase pim-3
Names
KID-1/kinase induced by depolarization
NP_663453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145478.2NP_663453.1  serine/threonine-protein kinase pim-3

    See identical proteins and their annotated locations for NP_663453.1

    Status: PROVISIONAL

    Source sequence(s)
    AC117700
    Consensus CDS
    CCDS27734.1
    UniProtKB/Swiss-Prot
    P58750
    UniProtKB/TrEMBL
    Q3TX64, Q811X8
    Related
    ENSMUSP00000044603.10, ENSMUST00000042818.11
    Conserved Domains (1) summary
    cl21453
    Location:39293
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    88746397..88749929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)