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Lin7b lin-7 homolog B, crumbs cell polarity complex component [ Mus musculus (house mouse) ]

Gene ID: 22342, updated on 8-Dec-2022

Summary

Official Symbol
Lin7bprovided by MGI
Official Full Name
lin-7 homolog B, crumbs cell polarity complex componentprovided by MGI
Primary source
MGI:MGI:1330858
See related
Ensembl:ENSMUSG00000003872 AllianceGenome:MGI:1330858
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Veli2; LIN-7B; MALS-2
Summary
Predicted to enable L27 domain binding activity and PDZ domain binding activity. Acts upstream of or within neurotransmitter secretion. Located in plasma membrane. Orthologous to human LIN7B (lin-7 homolog B, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 56.4), frontal lobe adult (RPKM 42.1) and 8 other tissues See more
Orthologs
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Genomic context

See Lin7b in Genome Data Viewer
Location:
7; 7 B3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45017315..45019988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45367891..45370564, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene histidine rich calcium binding protein Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 Neighboring gene metastasis associated gene 2 Neighboring gene small nuclear ribonucleoprotein 70 (U1) Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L27 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MPP7-DLG1-LIN7 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein lin-7 homolog B
Names
lin 7 homolog b
lin-7 homolog B
mammalian lin-seven protein 2
veli-2
vertebrate homolog of C. elegans Lin-7 type 2
vertebrate lin-7 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011698.1NP_035828.1  protein lin-7 homolog B

    See identical proteins and their annotated locations for NP_035828.1

    Status: PROVISIONAL

    Source sequence(s)
    AF173082
    Consensus CDS
    CCDS21239.1
    UniProtKB/Swiss-Prot
    O88951
    UniProtKB/TrEMBL
    A0A6P5Q5C3, A0A8C6HL38
    Related
    ENSMUSP00000003971.8, ENSMUST00000003971.10
    Conserved Domains (2) summary
    cd00992
    Location:91172
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:1466
    L27; L27 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45017315..45019988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)