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Vdac3 voltage-dependent anion channel 3 [ Mus musculus (house mouse) ]

Gene ID: 22335, updated on 6-Jun-2024

Summary

Official Symbol
Vdac3provided by MGI
Official Full Name
voltage-dependent anion channel 3provided by MGI
Primary source
MGI:MGI:106922
See related
Ensembl:ENSMUSG00000008892 AllianceGenome:MGI:106922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable voltage-gated anion channel activity. Acts upstream of or within behavioral fear response; learning; and neuron-neuron synaptic transmission. Located in mitochondrion. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 68.2), testis adult (RPKM 53.9) and 23 other tissues See more
Orthologs
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Genomic context

See Vdac3 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23067091..23083829, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22577075..22593813, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39140 Neighboring gene small integral membrane protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E9722 Neighboring gene solute carrier family 20, member 2 Neighboring gene STARR-seq mESC enhancer starr_20908 Neighboring gene predicted gene, 30086 Neighboring gene predicted gene, 30135

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102096

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables porin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-dependent anion-selective channel protein 3
Names
VDAC-3
channel protein VDAC3
mVDAC3
mitochondrial outer membrane protein
outer mitochondrial membrane protein porin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198998.1NP_001185927.1  voltage-dependent anion-selective channel protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001185927.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK002296, AK146957, BY103517
    UniProtKB/TrEMBL
    Q3TTN3, Q5EBQ0
    Conserved Domains (1) summary
    cd07306
    Location:5283
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
  2. NM_011696.2NP_035826.1  voltage-dependent anion-selective channel protein 3 isoform 2

    See identical proteins and their annotated locations for NP_035826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' coding region, compared to variant 1, and encodes an isoform (2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK002296, AK150741, BY103517
    Consensus CDS
    CCDS22179.1
    UniProtKB/Swiss-Prot
    Q60931, Q8BNG2
    UniProtKB/TrEMBL
    Q3TTN3, Q3TX38
    Related
    ENSMUSP00000009036.4, ENSMUST00000009036.11
    Conserved Domains (1) summary
    cd07306
    Location:5282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23067091..23083829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)