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FDXR ferredoxin reductase [ Homo sapiens (human) ]

Gene ID: 2232, updated on 11-Sep-2019

Summary

Official Symbol
FDXRprovided by HGNC
Official Full Name
ferredoxin reductaseprovided by HGNC
Primary source
HGNC:HGNC:3642
See related
Ensembl:ENSG00000161513 MIM:103270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADR; ADXR; ANOA
Summary
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Biased expression in adrenal (RPKM 75.2), testis (RPKM 17.3) and 5 other tissues See more
Orthologs

Genomic context

See FDXR in Genome Data Viewer
Location:
17q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74862497..74872994, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72858619..72869156, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 104 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene Sharpr-MPRA regulatory region 86 Neighboring gene fatty acid desaturase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
    Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
  • Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR), organism-specific biosystem (from REACTOME)
    Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR), organism-specific biosystemCholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) normally catalyses the side-chain cleavage of cholesterol to form pregnenolone. Defects in CYP11A1 can cause Adrenal insufficiency, con...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of metabolism, organism-specific biosystem (from REACTOME)
    Diseases of metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Electron transport from NADPH to Ferredoxin, organism-specific biosystem (from REACTOME)
    Electron transport from NADPH to Ferredoxin, organism-specific biosystemNADPH, ferredoxin reductase (FDXR, Adrenodoxin reductase), and ferredoxins (FDX1, FDX1L) comprise a short electron transport chain that provides electrons for biosynthesis of iron-sulfur clusters and...
  • Endogenous sterols, organism-specific biosystem (from REACTOME)
    Endogenous sterols, organism-specific biosystemA number of CYPs take part in cholesterol biosynthesis and elimination, thus playing an important role in maintaining cholesterol homeostasis. Under normal physiological conditions, cholesterol intak...
  • Metabolic disorders of biological oxidation enzymes, organism-specific biosystem (from REACTOME)
    Metabolic disorders of biological oxidation enzymes, organism-specific biosystemThe ability to process xenobiotica and many endogenous compounds is called biotransformation and is catalysed by enzymes mainly in the liver of higher organisms but also a number of other organs such...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Metabolism of steroid hormones, organism-specific biosystem (from REACTOME)
    Metabolism of steroid hormones, organism-specific biosystemSteroid hormones are synthesized primarily in the adrenal gland and gonads. They regulate energy metabolism and stress responses (glucocorticoids), salt balance (mineralocorticoids), and sexual devel...
  • Mitochondrial iron-sulfur cluster biogenesis, organism-specific biosystem (from REACTOME)
    Mitochondrial iron-sulfur cluster biogenesis, organism-specific biosystemIron-sulfur (Fe-S) proteins are localized in the cytosol, nucleus, and mitochondria of mammalian cells (reviewed in Stemmler et al. 2010, Rouault 2012, Bandyopadhyay et al. 2008, Lill 2009, Lill et a...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • Pregnenolone biosynthesis, organism-specific biosystem (from REACTOME)
    Pregnenolone biosynthesis, organism-specific biosystemThe first process in the synthesis of all steroid hormones is the synthesis of pregnenolone from cholesterol. In this process, cholesterol mobilized from cytosolic lipid droplets or from lysosomes is...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADPH-adrenodoxin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferredoxin-NADP+ reductase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
C21-steroid hormone biosynthetic process TAS
Traceable Author Statement
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
sterol metabolic process TAS
Traceable Author Statement
more info
 
ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NADPH:adrenodoxin oxidoreductase, mitochondrial
Names
AR
adrenodoxin reductase
adrenodoxin-NADP(+) reductase
epididymis secretory sperm binding protein
ferredoxin--NADP(+) reductase
NP_001244941.2
NP_001244942.2
NP_001244943.2
NP_001244944.1
NP_001244945.2
NP_004101.3
NP_077728.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258012.4NP_001244941.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an in-frame additional segment in the coding region, compared to variant 1. The resulting isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC087651, AK295307, AW590330
    Consensus CDS
    CCDS58595.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MT64
    Related
    ENSP00000416515.2, ENST00000442102.6
    Conserved Domains (1) summary
    PLN02852
    Location:30530
    PLN02852; ferredoxin-NADP+ reductase
  2. NM_001258013.4NP_001244942.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a longer and alternate segment in the 5' coding region, compared to variant 1. The resulting isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC087651, AK293208, AW590330, DA267443
    Consensus CDS
    CCDS58596.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MSZ4
    Related
    ENSP00000408595.2, ENST00000413947.6
    Conserved Domains (2) summary
    PLN02852
    Location:71518
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:74118
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_001258014.4NP_001244943.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame segment in the coding region, compared to variant 1. The resulting isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC087651, AK301779, AW590330
    Consensus CDS
    CCDS58592.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MTR6
    Related
    ENSP00000462183.1, ENST00000582944.5
    Conserved Domains (2) summary
    PLN02852
    Location:30479
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4393
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  4. NM_001258015.3NP_001244944.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 6 precursor

    See identical proteins and their annotated locations for NP_001244944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC087651, AK295307, AK298908, BC018911
    Consensus CDS
    CCDS58594.1
    UniProtKB/Swiss-Prot
    P22570
    Related
    ENSP00000414172.2, ENST00000420580.6
    Conserved Domains (2) summary
    PLN02852
    Location:30447
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4388
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  5. NM_001258016.3NP_001244945.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (7) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC087651, AK301779, AK301977, BC018911
    Consensus CDS
    CCDS58591.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MTN9
    Related
    ENSP00000445432.1, ENST00000544854.5
    Conserved Domains (1) summary
    COG0493
    Location:10435
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]
  6. NM_004110.6NP_004101.3  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_004101.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an in-frame additional segment in the coding region, compared to variant 1. The resulting isoform (2) is longer than isoform 1.
    Source sequence(s)
    AW590330, DA267443, J03826
    Consensus CDS
    CCDS11707.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0C4DGN7
    Related
    ENSP00000462972.1, ENST00000581530.5
    Conserved Domains (2) summary
    PLN02852
    Location:30493
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  7. NM_024417.5NP_077728.3  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_077728.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. It encodes isoform 1.
    Source sequence(s)
    BC018911, DA267443
    Consensus CDS
    CCDS58593.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0C4DFN8
    Related
    ENSP00000293195.5, ENST00000293195.10
    Conserved Domains (2) summary
    PLN02852
    Location:30487
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_047576.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate splice site at the 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087651, AK293210, AK295307, BC018911
    Related
    ENST00000577509.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74862497..74872994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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