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FDXR ferredoxin reductase [ Homo sapiens (human) ]

Gene ID: 2232, updated on 7-Jun-2020

Summary

Official Symbol
FDXRprovided by HGNC
Official Full Name
ferredoxin reductaseprovided by HGNC
Primary source
HGNC:HGNC:3642
See related
Ensembl:ENSG00000161513 MIM:103270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADR; ADXR; ANOA
Summary
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Biased expression in adrenal (RPKM 75.2), testis (RPKM 17.3) and 5 other tissues See more
Orthologs

Genomic context

See FDXR in Genome Data Viewer
Location:
17q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74862497..74872994, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72858619..72869156, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 104 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene Sharpr-MPRA regulatory region 86 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4853

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADPH-adrenodoxin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferredoxin-NADP+ reductase activity TAS
Traceable Author Statement
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
C21-steroid hormone biosynthetic process TAS
Traceable Author Statement
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
sterol metabolic process TAS
Traceable Author Statement
more info
 
ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NADPH:adrenodoxin oxidoreductase, mitochondrial
Names
AR
adrenodoxin reductase
adrenodoxin-NADP(+) reductase
epididymis secretory sperm binding protein
ferredoxin--NADP(+) reductase
NP_001244941.2
NP_001244942.2
NP_001244943.2
NP_001244944.1
NP_001244945.2
NP_004101.3
NP_077728.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258012.4NP_001244941.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an in-frame additional segment in the coding region, compared to variant 1. The resulting isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC087651, AK295307, AW590330
    Consensus CDS
    CCDS58595.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MT64
    Related
    ENSP00000416515.2, ENST00000442102.6
    Conserved Domains (1) summary
    PLN02852
    Location:30530
    PLN02852; ferredoxin-NADP+ reductase
  2. NM_001258013.4NP_001244942.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a longer and alternate segment in the 5' coding region, compared to variant 1. The resulting isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC087651, AK293208, AW590330, DA267443
    Consensus CDS
    CCDS58596.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MSZ4
    Related
    ENSP00000408595.2, ENST00000413947.6
    Conserved Domains (2) summary
    PLN02852
    Location:71518
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:74118
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_001258014.4NP_001244943.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame segment in the coding region, compared to variant 1. The resulting isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC087651, AK301779, AW590330
    Consensus CDS
    CCDS58592.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MTR6
    Related
    ENSP00000462183.1, ENST00000582944.5
    Conserved Domains (2) summary
    PLN02852
    Location:30479
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4393
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  4. NM_001258015.3NP_001244944.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 6 precursor

    See identical proteins and their annotated locations for NP_001244944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC087651, AK295307, AK298908, BC018911
    Consensus CDS
    CCDS58594.1
    UniProtKB/Swiss-Prot
    P22570
    Related
    ENSP00000414172.2, ENST00000420580.6
    Conserved Domains (2) summary
    PLN02852
    Location:30447
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4388
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  5. NM_001258016.3NP_001244945.2  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (7) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC087651, AK301779, AK301977, BC018911
    Consensus CDS
    CCDS58591.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0A0MTN9
    Related
    ENSP00000445432.1, ENST00000544854.5
    Conserved Domains (1) summary
    COG0493
    Location:10435
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]
  6. NM_004110.6NP_004101.3  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_004101.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an in-frame additional segment in the coding region, compared to variant 1. The resulting isoform (2) is longer than isoform 1.
    Source sequence(s)
    AW590330, DA267443, J03826
    Consensus CDS
    CCDS11707.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0C4DGN7
    Related
    ENSP00000462972.1, ENST00000581530.5
    Conserved Domains (2) summary
    PLN02852
    Location:30493
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  7. NM_024417.5NP_077728.3  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_077728.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. It encodes isoform 1.
    Source sequence(s)
    BC018911, DA267443
    Consensus CDS
    CCDS58593.1
    UniProtKB/Swiss-Prot
    P22570
    UniProtKB/TrEMBL
    A0A0C4DFN8
    Related
    ENSP00000293195.5, ENST00000293195.10
    Conserved Domains (2) summary
    PLN02852
    Location:30487
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_047576.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate splice site at the 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087651, AK293210, AK295307, BC018911
    Related
    ENST00000577509.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74862497..74872994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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