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PXT1 peroxisomal testis enriched protein 1 [ Homo sapiens (human) ]

Gene ID: 222659, updated on 25-Jan-2022

Summary

Official Symbol
PXT1provided by HGNC
Official Full Name
peroxisomal testis enriched protein 1provided by HGNC
Primary source
HGNC:HGNC:18312
See related
Ensembl:ENSG00000179165 AllianceGenome:HGNC:18312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STEPP
Summary
Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within spermatogenesis. Predicted to be active in nucleus and peroxisome. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 1.3), bone marrow (RPKM 0.1) and 1 other tissue See more
Orthologs
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Genomic context

See PXT1 in Genome Data Viewer
Location:
6p21.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (36390551..36442854, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36358328..36410631, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein 5 Neighboring gene ETS variant transcription factor 7 Neighboring gene ETV7 and PTX1 antisense RNA 1 Neighboring gene PXT1 intron CAGE-defined low expression enhancer Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene serine/threonine kinase 38 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
peroxisomal testis-specific protein 1
Names
peroxisomal, testis specific 1
small testis-specific peroxisomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152990.4NP_694535.2  peroxisomal testis-specific protein 1

    See identical proteins and their annotated locations for NP_694535.2

    Status: VALIDATED

    Source sequence(s)
    AL133263, BC031105
    Consensus CDS
    CCDS4820.2
    UniProtKB/Swiss-Prot
    Q8NFP0
    Related
    ENSP00000419944.1, ENST00000454782.3
    Conserved Domains (1) summary
    pfam15214
    Location:85134
    PXT1; Peroxisomal testis-specific protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    36390551..36442854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514400.2XP_011512702.1  peroxisomal testis-specific protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15214
    Location:90139
    PXT1; Peroxisomal testis-specific protein 1
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