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HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 [ Homo sapiens (human) ]

Gene ID: 222537, updated on 3-Oct-2018

Summary

Official Symbol
HS3ST5provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 5provided by HGNC
Primary source
HGNC:HGNC:19419
See related
Ensembl:ENSG00000249853 MIM:609407; Vega:OTTHUMG00000015412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3OST5; 3-OST-5; HS3OST5; NBLA04021
Summary
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HS3ST5 in Genome Data Viewer
Location:
6q21-q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (114055586..114342395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114376750..114663540, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene histone deacetylase 2 Neighboring gene HDAC2 and HS3ST5 antisense RNA 2 Neighboring gene nudix hydrolase 19 pseudogene 3 Neighboring gene ribosomal protein SA pseudogene 43 Neighboring gene RNA, 5S ribosomal pseudogene 213 Neighboring gene uncharacterized LOC107986638 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 4 Neighboring gene uncharacterized LOC105377959

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
NHGRI GWA Catalog

Pathways from BioSystems

  • Glycosaminoglycan biosynthesis - heparan sulfate / heparin, organism-specific biosystem (from KEGG)
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin, organism-specific biosystemHeparan sulfate (HS) and heparin (Hep) are glycosaminoglycans with repeating disaccharide units that consist of alternating residues of alpha-D-glucosamine (GlcN) and uronic acid, the latter being ei...
  • Glycosaminoglycan biosynthesis - heparan sulfate / heparin, conserved biosystem (from KEGG)
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin, conserved biosystemHeparan sulfate (HS) and heparin (Hep) are glycosaminoglycans with repeating disaccharide units that consist of alternating residues of alpha-D-glucosamine (GlcN) and uronic acid, the latter being ei...
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • HS-GAG biosynthesis, organism-specific biosystem (from REACTOME)
    HS-GAG biosynthesis, organism-specific biosystemHeparan sulfate (HS) and heparin (sometimes collectively called HS-GAG) consist of the disaccharide unit GlcNAc-GlcA (N-acetylglucosamine-glucuronic acid) connected by a beta1,4 linkage. Heparin is e...
  • Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystem (from REACTOME)
    Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystemThe acronym HS-GAG is used to describe both heparin and heparan sulfate. HS-GAG is a member of the glycosaminoglycan family and consists of a variably sulfated repeating disaccharide unit, the most ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • heparan sulfate biosynthesis, organism-specific biosystem (from BIOCYC)
    heparan sulfate biosynthesis, organism-specific biosystem
    heparan sulfate biosynthesis
  • heparan sulfate biosynthesis (late stages), organism-specific biosystem (from BIOCYC)
    heparan sulfate biosynthesis (late stages), organism-specific biosystemBackground : Heparan-Sulfate "Heparan sulfate" is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three heparan sulfate chains are attached to cell s...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 5
Names
h3-OST-5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
heparan sulfate 3-O-sulfotransferase 5
heparan sulfate 3-OST-5
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
NP_705840.2
XP_006715442.1
XP_011533890.1
XP_016865959.1
XP_016865960.1
XP_016865961.1
XP_016865962.1
XP_016865963.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153612.3NP_705840.2  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_705840.2

    Status: VALIDATED

    Source sequence(s)
    AL355498
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    Q8IZT8
    Related
    ENSP00000440332.1, ENST00000411826.1
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    114055586..114342395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010474.2XP_016865963.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_006715379.2XP_006715442.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006715442.1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Related
    ENSP00000427888.1, OTTHUMP00000227139, ENST00000312719.9, OTTHUMT00000041911
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_017010473.1XP_016865962.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  4. XM_017010470.1XP_016865959.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  5. XM_017010471.1XP_016865960.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  6. XM_017010472.1XP_016865961.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  7. XM_011535588.2XP_011533890.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_011533890.1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
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