Format

Send to:

Choose Destination

HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 [ Homo sapiens (human) ]

Gene ID: 222537, updated on 1-Jun-2020

Summary

Official Symbol
HS3ST5provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 5provided by HGNC
Primary source
HGNC:HGNC:19419
See related
Ensembl:ENSG00000249853 MIM:609407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3OST5; 3-OST-5; HS3OST5; NBLA04021
Summary
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HS3ST5 in Genome Data Viewer
Location:
6q21-q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (114055586..114342395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114376750..114663540, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene histone deacetylase 2 Neighboring gene HDAC2 and HS3ST5 antisense RNA 2 Neighboring gene NUDT19 pseudogene 3 Neighboring gene ribosomal protein SA pseudogene 43 Neighboring gene RNA, 5S ribosomal pseudogene 213 Neighboring gene uncharacterized LOC107986638 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 4 Neighboring gene uncharacterized LOC105377959

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate binding NAS
Non-traceable Author Statement
more info
PubMed 
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 5
Names
h3-OST-5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
heparan sulfate 3-O-sulfotransferase 5
heparan sulfate 3-OST-5
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
NP_705840.2
XP_006715442.1
XP_011533890.1
XP_016865959.1
XP_016865960.1
XP_016865961.1
XP_016865962.1
XP_016865963.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153612.3NP_705840.2  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_705840.2

    Status: VALIDATED

    Source sequence(s)
    AL355498
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    Q8IZT8
    Related
    ENSP00000440332.1, ENST00000411826.1
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    114055586..114342395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010474.2XP_016865963.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_006715379.2XP_006715442.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006715442.1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Related
    ENSP00000427888.1, ENST00000312719.9
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_017010473.1XP_016865962.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  4. XM_017010470.1XP_016865959.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  5. XM_017010471.1XP_016865960.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  6. XM_017010472.1XP_016865961.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
  7. XM_011535588.2XP_011533890.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_011533890.1

    UniProtKB/Swiss-Prot
    Q8IZT8
    Conserved Domains (1) summary
    pfam00685
    Location:90330
    Sulfotransfer_1; Sulfotransferase domain
Support Center