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ADGRG3 adhesion G protein-coupled receptor G3 [ Homo sapiens (human) ]

Gene ID: 222487, updated on 13-Mar-2020

Summary

Official Symbol
ADGRG3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G3provided by HGNC
Primary source
HGNC:HGNC:13728
See related
Ensembl:ENSG00000182885 MIM:618441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PB99; GPR97; PGR26
Expression
Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue See more
Orthologs

Genomic context

See ADGRG3 in Genome Data Viewer
Location:
16q21
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57663998..57689378)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57702099..57723290)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371291 Neighboring gene uncharacterized LOC107984889 Neighboring gene high mobility group box 3 pseudogene 32 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene mitochondrial carrier 2 pseudogene Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NIK/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor G3
Names
G protein-coupled receptor 97
G-protein coupled receptor PGR26
probable G-protein coupled receptor 97

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308360.2NP_001295289.1  adhesion G protein-coupled receptor G3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR and 5' coding region resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC018552, AK172801, AK301258, BC044222
    Consensus CDS
    CCDS76879.1
    UniProtKB/Swiss-Prot
    Q86Y34
    UniProtKB/TrEMBL
    B4DVW2, F8W8F7
    Related
    ENSP00000404803.3, ENST00000450388.7
    Conserved Domains (2) summary
    pfam01825
    Location:93135
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:148397
    7tm_4; Olfactory receptor
  2. NM_170776.5NP_740746.4  adhesion G protein-coupled receptor G3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_740746.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018552, BC064508, BE672513
    Consensus CDS
    CCDS10786.1
    UniProtKB/Swiss-Prot
    Q86Y34
    Related
    ENSP00000332900.4, ENST00000333493.9
    Conserved Domains (2) summary
    pfam01825
    Location:213255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:268517
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57663998..57689378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522951.3XP_011521253.1  adhesion G protein-coupled receptor G3 isoform X2

    Conserved Domains (2) summary
    pfam01825
    Location:93135
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:235444
    7tm_4; Olfactory receptor
  2. XM_005255842.4XP_005255899.1  adhesion G protein-coupled receptor G3 isoform X1

    Conserved Domains (2) summary
    pfam01825
    Location:213255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:355564
    7tm_4; Olfactory receptor
  3. XM_011522953.3XP_011521255.1  adhesion G protein-coupled receptor G3 isoform X3

    Conserved Domains (2) summary
    pfam01825
    Location:213255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:274392
    7tm_4; Olfactory receptor
  4. XM_006721170.4XP_006721233.1  adhesion G protein-coupled receptor G3 isoform X5

    Conserved Domains (1) summary
    pfam01825
    Location:213255
    GPS; GPCR proteolysis site, GPS, motif
  5. XM_011522954.2XP_011521256.1  adhesion G protein-coupled receptor G3 isoform X4

    Conserved Domains (1) summary
    pfam01825
    Location:213255
    GPS; GPCR proteolysis site, GPS, motif

RNA

  1. XR_243399.3 RNA Sequence

    Related
    ENST00000567991.5
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