U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADGRG3 adhesion G protein-coupled receptor G3 [ Homo sapiens (human) ]

Gene ID: 222487, updated on 25-Nov-2025
Official Symbol
ADGRG3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G3provided by HGNC
Primary source
HGNC:HGNC:13728
See related
Ensembl:ENSG00000182885 MIM:618441; AllianceGenome:HGNC:13728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PB99; GPR97; PGR26
Summary
Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ADGRG3 in Genome Data Viewer
Location:
16q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57665629..57689378)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63460829..63484584)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57702218..57723290)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10904 Neighboring gene high mobility group box 3 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57653277-57653781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57653782-57654285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57654286-57654790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57656181-57657035 Neighboring gene Sharpr-MPRA regulatory region 10529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57661723-57662378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57662379-57663034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57665003-57665658 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57685116-57685516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57692922-57693920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57693921-57694919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57710685-57711625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10909 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene MTCH2 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57767533-57768510 Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7536 Neighboring gene katanin regulatory subunit B1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid. Harada N, et al. Biochem Biophys Res Commun, 2022 Mar 5. PMID 35093639, Free PMC Article
  2. Ca2+-binding modulator protein in protozoa and myxomycete. Kuźnicki J, et al. Cell Biol Int Rep, 1979 Jan. PMID 222487
  3. The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions. Hsiao CC, et al. Front Immunol, 2018. PMID 30559745, Free PMC Article
  4. Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex. Ping YQ, et al. Nature, 2021 Jan. PMID 33408414
  5. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Chu TY, et al. Nat Commun, 2022 Oct 27. PMID 36302784, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.
    Title: GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.
  2. Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.
    Title: Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.
  3. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.
    Title: Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex.
  4. Ligation of GPR97 increased the bacteria uptake.
    Title: The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.
  5. a possible role of GPR97 in lymphatic remodeling
    Title: The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
Preferred Names
adhesion G protein-coupled receptor G3
Names
G protein-coupled receptor 97
G-protein coupled receptor PGR26
probable G-protein coupled receptor 97

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308360.2 → NP_001295289.1  adhesion G protein-coupled receptor G3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR and 5' coding region resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC018552, AK172801, AK301258, BC044222
    Consensus CDS
    CCDS76879.1
    UniProtKB/TrEMBL
    B4DVW2, F8W8F7
    Related
    ENSP00000404803.3, ENST00000450388.7
    Conserved Domains (2) summary
    pfam01825
    Location:93 → 135
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:148 → 397
    7tm_4; Olfactory receptor

  2. NM_170776.5 → NP_740746.4  adhesion G protein-coupled receptor G3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_740746.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018552, BC064508, BE672513
    Consensus CDS
    CCDS10786.1
    UniProtKB/Swiss-Prot
    Q6ZMF4, Q86SL9, Q86Y34, Q8IZF1
    Related
    ENSP00000332900.4, ENST00000333493.9
    Conserved Domains (2) summary
    pfam01825
    Location:213 → 255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:268 → 517
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57665629..57689378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433780.1 → XP_047289736.1  adhesion G protein-coupled receptor G3 isoform X2

  2. XM_005255842.5 → XP_005255899.1  adhesion G protein-coupled receptor G3 isoform X1

    Related
    ENSP00000615198.1, ENST00000945139.1
    Conserved Domains (2) summary
    pfam01825
    Location:213 → 255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:355 → 564
    7tm_4; Olfactory receptor

  3. XM_011522953.4 → XP_011521255.1  adhesion G protein-coupled receptor G3 isoform X4

    Related
    ENSP00000528918.1, ENST00000858859.1
    Conserved Domains (2) summary
    pfam01825
    Location:213 → 255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:274 → 392
    7tm_4; Olfactory receptor

  4. XM_006721170.5 → XP_006721233.1  adhesion G protein-coupled receptor G3 isoform X6

    Conserved Domains (1) summary
    pfam01825
    Location:213 → 255
    GPS; GPCR proteolysis site, GPS, motif

  5. XM_011522954.3 → XP_011521256.1  adhesion G protein-coupled receptor G3 isoform X5

    Conserved Domains (1) summary
    pfam01825
    Location:213 → 255
    GPS; GPCR proteolysis site, GPS, motif

  6. XM_047433782.1 → XP_047289738.1  adhesion G protein-coupled receptor G3 isoform X7

    UniProtKB/TrEMBL
    H3BRU4
    Related
    ENSP00000456409.1, ENST00000567991.5

  7. XM_047433783.1 → XP_047289739.1  adhesion G protein-coupled receptor G3 isoform X8

  8. XM_047433781.1 → XP_047289737.1  adhesion G protein-coupled receptor G3 isoform X3

    UniProtKB/TrEMBL
    B4DVW2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63460829..63484584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379819.1 → XP_054235794.1  adhesion G protein-coupled receptor G3 isoform X2

  2. XM_054379818.1 → XP_054235793.1  adhesion G protein-coupled receptor G3 isoform X1

  3. XM_054379821.1 → XP_054235796.1  adhesion G protein-coupled receptor G3 isoform X4

  4. XM_054379823.1 → XP_054235798.1  adhesion G protein-coupled receptor G3 isoform X6

  5. XM_054379822.1 → XP_054235797.1  adhesion G protein-coupled receptor G3 isoform X5

  6. XM_054379824.1 → XP_054235799.1  adhesion G protein-coupled receptor G3 isoform X7

    UniProtKB/TrEMBL
    H3BRU4

  7. XM_054379825.1 → XP_054235800.1  adhesion G protein-coupled receptor G3 isoform X8

  8. XM_054379820.1 → XP_054235795.1  adhesion G protein-coupled receptor G3 isoform X3

    UniProtKB/TrEMBL
    B4DVW2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86Y34.1 GenPept UniProtKB/Swiss-Prot:Q86Y34

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous