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Ubr1 ubiquitin protein ligase E3 component n-recognin 1 [ Mus musculus (house mouse) ]

Gene ID: 22222, updated on 12-Aug-2019

Summary

Official Symbol
Ubr1provided by MGI
Official Full Name
ubiquitin protein ligase E3 component n-recognin 1provided by MGI
Primary source
MGI:MGI:1277977
See related
Ensembl:ENSMUSG00000027272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI504731
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.7), CNS E18 (RPKM 5.5) and 28 other tissues See more
Orthologs

Genomic context

See Ubr1 in Genome Data Viewer
Location:
2 E5; 2 60.37 cM
Exon count:
48
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120860272..120970760, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120686008..120796451, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene START domain containing 9 Neighboring gene congenital dyserythropoietic anemia, type I (human) Neighboring gene tau tubulin kinase 2 Neighboring gene expressed sequence AV039307 Neighboring gene transmembrane protein 62 Neighboring gene U3B small nuclear RNA pseudogene 2 Neighboring gene cyclin D-type binding-protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
leucine binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to leucine ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome complex IGI
Inferred from Genetic Interaction
more info
PubMed 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UBR1
Names
E3 alpha
N-recognin-1
RING-type E3 ubiquitin transferase UBR1
ubiquitin-protein ligase E3-alpha-1
ubiquitin-protein ligase E3-alpha-I
ubiquitin-protein ligase e3 componen n-recognin
NP_033487.2
XP_006499227.1
XP_011237742.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009461.2NP_033487.2  E3 ubiquitin-protein ligase UBR1

    See identical proteins and their annotated locations for NP_033487.2

    Status: VALIDATED

    Source sequence(s)
    AL844548, AL935168
    Consensus CDS
    CCDS16628.1
    UniProtKB/Swiss-Prot
    O70481
    Related
    ENSMUSP00000028728.5, ENSMUST00000028728.5
    Conserved Domains (2) summary
    pfam02207
    Location:99166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:221301
    ClpS; ATP-dependent Clp protease adaptor protein ClpS

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    120860272..120970760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499164.3XP_006499227.1  E3 ubiquitin-protein ligase UBR1 isoform X1

    Conserved Domains (2) summary
    pfam02207
    Location:99166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:221301
    ClpS; ATP-dependent Clp protease adaptor protein ClpS
  2. XM_011239440.3XP_011237742.1  E3 ubiquitin-protein ligase UBR1 isoform X2

    Conserved Domains (1) summary
    cl17238
    Location:329447
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_003952079.1 RNA Sequence

  2. XR_003952081.1 RNA Sequence

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