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SRRM3 serine/arginine repetitive matrix 3 [ Homo sapiens (human) ]

Gene ID: 222183, updated on 6-Sep-2022

Summary

Official Symbol
SRRM3provided by HGNC
Official Full Name
serine/arginine repetitive matrix 3provided by HGNC
Primary source
HGNC:HGNC:26729
See related
Ensembl:ENSG00000177679 AllianceGenome:HGNC:26729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mRNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal (RPKM 3.7), brain (RPKM 3.0) and 17 other tissues See more
Orthologs
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Genomic context

Location:
7q11.23
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (76201896..76287287)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (77489369..77574760)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75831214..75916604)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene GTF2I repeat domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5015 Neighboring gene uncharacterized LOC124901679 Neighboring gene Sharpr-MPRA regulatory region 1121 Neighboring gene CRISPRi-validated cis-regulatory element chr7.2946 Neighboring gene Sharpr-MPRA regulatory region 11180

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35271, FLJ37078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/arginine repetitive matrix protein 3
Names
SRRM2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110199.3NP_001103669.1  serine/arginine repetitive matrix protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC005077, AI815474, AK092590, BC029292, BE466083, CA502814
    UniProtKB/TrEMBL
    A0A087WXA3
    Related
    ENSP00000480851.1, ENST00000611745.2
    Conserved Domains (2) summary
    pfam08312
    Location:5698
    cwf21; cwf21 domain
    pfam15230
    Location:531584
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus
  2. NM_001291831.2NP_001278760.1  serine/arginine repetitive matrix protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC005077, AI815474, BC029292, BC071856
    Conserved Domains (2) summary
    pfam08312
    Location:5698
    cwf21; cwf21 domain
    pfam15230
    Location:531577
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    76201896..76287287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    77489369..77574760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039212.1: Suppressed sequence

    Description
    NM_001039212.1: This RefSeq was permanently suppressed because it is primarily UTR sequence, and it contains the wrong CDS.
  2. NM_153043.3: Suppressed sequence

    Description
    NM_153043.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.