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Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Mus musculus (house mouse) ]

Gene ID: 22195, updated on 9-Jun-2024

Summary

Official Symbol
Ube2l3provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2L 3provided by MGI
Primary source
MGI:MGI:109240
See related
Ensembl:ENSMUSG00000038965 AllianceGenome:MGI:109240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UbcM4; Ubce7
Summary
Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; heart; immune system; lung; and reproductive system. Orthologous to human UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 45.0), liver E14 (RPKM 37.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ube2l3 in Genome Data Viewer
Location:
16 A3; 16 10.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16969879..17019363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17152015..17201512, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rps20 pseudogene Neighboring gene coiled-coil domain containing 116 Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129 Neighboring gene RIMS binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Transgenic (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118100

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 L3
Names
E2 ubiquitin-conjugating enzyme L3
ubiquitin carrier protein L3
ubiquitin-conjugating enzyme 7
ubiquitin-protein ligase L3
NP_001406151.1
NP_001406152.1
NP_001406153.1
NP_001406154.1
NP_001406155.1
NP_001406156.1
NP_001406158.1
NP_033482.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419222.1NP_001406151.1  ubiquitin-conjugating enzyme E2 L3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    Q3TIH9
  2. NM_001419223.1NP_001406152.1  ubiquitin-conjugating enzyme E2 L3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    A0A338P786
    Related
    ENSMUSP00000156283.2, ENSMUST00000232668.2
  3. NM_001419224.1NP_001406153.1  ubiquitin-conjugating enzyme E2 L3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    A0A338P786
  4. NM_001419225.1NP_001406154.1  ubiquitin-conjugating enzyme E2 L3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    Q3TIH9
  5. NM_001419226.1NP_001406155.1  ubiquitin-conjugating enzyme E2 L3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    A0A338P7E5
    Related
    ENSMUSP00000156336.2, ENSMUST00000231643.2
  6. NM_001419227.1NP_001406156.1  ubiquitin-conjugating enzyme E2 L3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154667
  7. NM_001419229.1NP_001406158.1  ubiquitin-conjugating enzyme E2 L3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    A0A338P702
    Related
    ENSMUSP00000156034.2, ENSMUST00000232035.2
  8. NM_009456.3NP_033482.1  ubiquitin-conjugating enzyme E2 L3 isoform 1

    See identical proteins and their annotated locations for NP_033482.1

    Status: VALIDATED

    Source sequence(s)
    AC154667
    Consensus CDS
    CCDS27997.1
    UniProtKB/Swiss-Prot
    P68037
    UniProtKB/TrEMBL
    Q3TIH9, Q561N4
    Related
    ENSMUSP00000087658.6, ENSMUST00000090192.12
    Conserved Domains (1) summary
    smart00212
    Location:6149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RNA

  1. NR_185043.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667
  2. NR_185044.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667
  3. NR_185045.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667
  4. NR_185046.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667
  5. NR_185047.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16969879..17019363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)