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Tyr tyrosinase [ Mus musculus (house mouse) ]

Gene ID: 22173, updated on 6-Jun-2024

Summary

Official Symbol
Tyrprovided by MGI
Official Full Name
tyrosinaseprovided by MGI
Primary source
MGI:MGI:98880
See related
Ensembl:ENSMUSG00000004651 AllianceGenome:MGI:98880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c; Oca1; skc35; albino
Summary
Enables protein homodimerization activity. Acts upstream of or within several processes, including melanin biosynthetic process; pigmentation; and thymus development. Located in melanosome. Is expressed in central nervous system; eye; head mesenchyme; mesenchyme derived from neural crest; and skin. Used to study buphthalmos and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tyr in Genome Data Viewer
Location:
7 D3; 7 49.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (87073979..87142637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (87424771..87493512, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene NADPH oxidase 4 Neighboring gene STARR-seq mESC enhancer starr_19472 Neighboring gene STARR-seq mESC enhancer starr_19473 Neighboring gene tyrosinase locus control region Neighboring gene predicted gene, 57515 Neighboring gene tyrosinase CNS-2 distal regulatory element Neighboring gene glutamate receptor, metabotropic 5 Neighboring gene splicing factor 3a, subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tyrosinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tyrosinase activity ISO
Inferred from Sequence Orthology
more info
 
enables tyrosinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within melanin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pigmentation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to blue light ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosinase
Names
albino locus protein
monophenol monooxygenase
NP_001304326.1
NP_001404377.1
NP_035791.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317397.2NP_001304326.1  tyrosinase isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122517, AC141329
    UniProtKB/TrEMBL
    Q3UFQ7
    Conserved Domains (1) summary
    pfam00264
    Location:171354
    Tyrosinase; Common central domain of tyrosinase
  2. NM_001417448.1NP_001404377.1  tyrosinase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122517
    UniProtKB/TrEMBL
    Q3UFQ7
    Related
    ENSMUST00000207164.2
  3. NM_011661.6NP_035791.1  tyrosinase isoform 1 precursor

    See identical proteins and their annotated locations for NP_035791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122517, AC141329
    Consensus CDS
    CCDS52304.1
    UniProtKB/Swiss-Prot
    P11344
    UniProtKB/TrEMBL
    Q3UFK9, Q91XK0
    Related
    ENSMUSP00000004770.6, ENSMUST00000004770.7
    Conserved Domains (1) summary
    pfam00264
    Location:171403
    Tyrosinase; Common central domain of tyrosinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    87073979..87142637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)