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Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22164, updated on 8-Feb-2024

Summary

Official Symbol
Tnfsf4provided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 4provided by MGI
Primary source
MGI:MGI:104511
See related
Ensembl:ENSMUSG00000026700 AllianceGenome:MGI:104511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Tnlg2b; Txgp1l
Summary
Enables tumor necrosis factor receptor binding activity. Involved in several processes, including T cell activation; regulation of gene expression; and regulation of lymphocyte activation. Acts upstream of or within cholesterol metabolic process; inflammatory response; and negative regulation of cytokine production. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in sensory organ and skeleton. Used to study primary pulmonary hypertension and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human TNFSF4 (TNF superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tnfsf4 in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161223009..161245777)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161395438..161418206)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02818 Neighboring gene STARR-positive B cell enhancer ABC_E9490 Neighboring gene STARR-positive B cell enhancer ABC_E5834 Neighboring gene STARR-seq mESC enhancer starr_02820 Neighboring gene peroxiredoxin 6 Neighboring gene STARR-seq mESC enhancer starr_02821 Neighboring gene STARR-seq mESC enhancer starr_02822 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02823 Neighboring gene STARR-seq mESC enhancer starr_02824 Neighboring gene STARR-seq mESC enhancer starr_02825 Neighboring gene STARR-positive B cell enhancer mm9_chr1:163430931-163431231 Neighboring gene tumor necrosis factor (ligand) superfamily, member 18 Neighboring gene STARR-seq mESC enhancer starr_02826 Neighboring gene predicted gene, 31815

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor superfamily binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tumor necrosis factor receptor superfamily binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor superfamily binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 2 cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to nitrogen dioxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to nematode IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inflammatory response IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in memory T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell apoptotic process IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of T-helper 1 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of activation-induced cell death of T cells IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CD4-positive, alpha-beta T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T-helper 2 cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of immune effector process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-13 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4-dependent isotype switching to IgE isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of memory T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of memory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type 2 immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nitrogen dioxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 4
Names
OX40 ligand
atherosclerosis 1
tax-transcriptionally activated glycoprotein 1 ligand
tumor necrosis factor ligand 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009452.2NP_033478.1  tumor necrosis factor ligand superfamily member 4

    See identical proteins and their annotated locations for NP_033478.1

    Status: VALIDATED

    Source sequence(s)
    AC163268, BY208852, FJ176943
    Consensus CDS
    CCDS15416.1
    UniProtKB/Swiss-Prot
    P43488
    UniProtKB/TrEMBL
    B6DXE3
    Related
    ENSMUSP00000028024.5, ENSMUST00000028024.5
    Conserved Domains (1) summary
    smart00207
    Location:74187
    TNF; Tumour necrosis factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    161223009..161245777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)