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Tubb4a tubulin, beta 4A class IVA [ Mus musculus (house mouse) ]

Gene ID: 22153, updated on 18-Apr-2024

Summary

Official Symbol
Tubb4aprovided by MGI
Official Full Name
tubulin, beta 4A class IVAprovided by MGI
Primary source
MGI:MGI:107848
See related
Ensembl:ENSMUSG00000062591 AllianceGenome:MGI:107848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tubb; Tubb4; M(beta)4
Summary
Predicted to enable GTP binding activity and calcium ion binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and negative regulation of microtubule polymerization. Predicted to act upstream of or within cell projection organization. Located in several cellular components, including internode region of axon; myelin sheath; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study hypomyelinating leukodystrophy 6. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 289.9), cortex adult (RPKM 152.4) and 6 other tissues See more
Orthologs
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Genomic context

Location:
17 D; 17 29.66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57387061..57394600, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57080061..57087600, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene crumbs family member 3 Neighboring gene DENN domain containing 1C Neighboring gene predicted gene 11110 Neighboring gene predicted gene, 46589 Neighboring gene tumor necrosis factor (ligand) superfamily, member 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in internode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulin beta-4A chain
Names
tubulin beta-4 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009451.4NP_033477.2  tubulin beta-4A chain

    See identical proteins and their annotated locations for NP_033477.2

    Status: VALIDATED

    Source sequence(s)
    AI837276, BC049112
    Consensus CDS
    CCDS28925.1
    UniProtKB/Swiss-Prot
    Q62364, Q80Y54, Q9D6F9
    UniProtKB/TrEMBL
    Q3U9U3
    Related
    ENSMUSP00000071135.6, ENSMUST00000071135.6
    Conserved Domains (1) summary
    PLN00220
    Location:1427
    PLN00220; tubulin beta chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57387061..57394600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)