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Tubb3 tubulin, beta 3 class III [ Mus musculus (house mouse) ]

Gene ID: 22152, updated on 18-Apr-2024

Summary

Official Symbol
Tubb3provided by MGI
Official Full Name
tubulin, beta 3 class IIIprovided by MGI
Primary source
MGI:MGI:107813
See related
Ensembl:ENSMUSG00000062380 AllianceGenome:MGI:107813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M(beta)3; M(beta)6; 3200002H15Rik
Summary
Enables netrin receptor binding activity. Involved in axon guidance and netrin-activated signaling pathway. Located in several cellular components, including filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; embryo ectoderm; nervous system; and sensory organ. Used to study congenital fibrosis of the extraocular muscles. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Orthologous to human TUBB3 (tubulin beta 3 class III). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 1032.5), whole brain E14.5 (RPKM 1029.6) and 5 other tissues See more
Orthologs
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Genomic context

Location:
8 E1; 8 72.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124138292..124148754)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123411553..123422015)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2278 Neighboring gene transcription factor 25 (basic helix-loop-helix) Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125928490-125928752 Neighboring gene STARR-seq mESC enhancer starr_22972 Neighboring gene melanocortin 1 receptor Neighboring gene differentially expressed in FDCP 8 Neighboring gene predicted gene, 39275

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables netrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables netrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal root ganglion development ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in netrin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulin beta-3 chain
Names
betaIII-tubulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023279.3NP_075768.1  tubulin beta-3 chain

    See identical proteins and their annotated locations for NP_075768.1

    Status: VALIDATED

    Source sequence(s)
    AK082942, BC031357, CK780733
    Consensus CDS
    CCDS22757.1
    UniProtKB/Swiss-Prot
    Q3UF42, Q5I036, Q9ERD7
    UniProtKB/TrEMBL
    Q3U9U3
    Related
    ENSMUSP00000071134.4, ENSMUST00000071134.4
    Conserved Domains (1) summary
    PLN00220
    Location:1447
    PLN00220; tubulin beta chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124138292..124148754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)