U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tuba4a tubulin, alpha 4A [ Mus musculus (house mouse) ]

Gene ID: 22145, updated on 21-Feb-2023

Summary

Official Symbol
Tuba4aprovided by MGI
Official Full Name
tubulin, alpha 4Aprovided by MGI
Primary source
MGI:MGI:1095410
See related
Ensembl:ENSMUSG00000026202 AllianceGenome:MGI:1095410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M[a]4; Tuba4
Summary
Enables enzyme binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in early embryo; lung; nervous system; and retina layer. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 120.6), liver E14.5 (RPKM 60.0) and 20 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tuba4a in Genome Data Viewer
Location:
1; 1 C4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75191616..75197905, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75214972..75221261, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene protein tyrosine phosphatase, receptor type, N

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tubulin alpha-4A chain
Names
alpha-tubulin isotype M-alpha-4
tubulin alpha-4 chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313723.1NP_001300652.1  tubulin alpha-4A chain isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC166150
    Conserved Domains (1) summary
    cl25946
    Location:1246
    Tubulin; Tubulin/FtsZ family, GTPase domain
  2. NM_001313724.1NP_001300653.1  tubulin alpha-4A chain isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment in the 3' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC166150
    Conserved Domains (1) summary
    PTZ00335
    Location:1295
    PTZ00335; tubulin alpha chain; Provisional
  3. NM_009447.4NP_033473.1  tubulin alpha-4A chain isoform 1

    See identical proteins and their annotated locations for NP_033473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK078355, AK158934, CK620957
    Consensus CDS
    CCDS35623.1
    UniProtKB/Swiss-Prot
    P68368, Q3TY31
    UniProtKB/TrEMBL
    A0A8C6HJF8
    Related
    ENSMUSP00000140657.2, ENSMUST00000186213.7
    Conserved Domains (1) summary
    PTZ00335
    Location:1448
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75191616..75197905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496478.2XP_006496541.1  tubulin alpha-4A chain isoform X1

    See identical proteins and their annotated locations for XP_006496541.1

    Conserved Domains (1) summary
    PTZ00335
    Location:1433
    PTZ00335; tubulin alpha chain; Provisional