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Ttr transthyretin [ Mus musculus (house mouse) ]

Gene ID: 22139, updated on 12-Aug-2019

Summary

Official Symbol
Ttrprovided by MGI
Official Full Name
transthyretinprovided by MGI
Primary source
MGI:MGI:98865
See related
Ensembl:ENSMUSG00000061808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17860; AA408768; AI787086; prealbumin
Summary
This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]
Expression
Biased expression in liver adult (RPKM 3655.3), liver E18 (RPKM 2930.2) and 7 other tissues See more
Orthologs

Genomic context

See Ttr in Genome Data Viewer
Location:
18 A2; 18 11.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20664209..20674326)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (20823751..20832827)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene triosephosphate isomerase related sequence 10 Neighboring gene predicted gene, 46630 Neighboring gene desmoglein 2 Neighboring gene predicted gene 16090 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 Neighboring gene predicted gene, 31437

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107649

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
hormone binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
thyroid hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
purine nucleobase metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013697.5NP_038725.1  transthyretin precursor

    See identical proteins and their annotated locations for NP_038725.1

    Status: REVIEWED

    Source sequence(s)
    AC129078, CD742426
    Consensus CDS
    CCDS29085.1
    UniProtKB/Swiss-Prot
    P07309
    UniProtKB/TrEMBL
    Q5M9K1
    Related
    ENSMUSP00000074783.3, ENSMUST00000075312.4
    Conserved Domains (1) summary
    smart00095
    Location:27147
    TR_THY; Transthyretin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p6 C57BL/6J

    Range
    20664209..20674326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250412.1XP_030106272.1  transthyretin isoform X1

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