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CALHM4 calcium homeostasis modulator family member 4 [ Homo sapiens (human) ]

Gene ID: 221301, updated on 23-Nov-2021

Summary

Official Symbol
CALHM4provided by HGNC
Official Full Name
calcium homeostasis modulator family member 4provided by HGNC
Primary source
HGNC:HGNC:21094
See related
Ensembl:ENSG00000164451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM26D; C6orf78
Expression
Restricted expression toward placenta (RPKM 4.4) See more
Orthologs
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Genomic context

See CALHM4 in Genome Data Viewer
Location:
6q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (116529021..116561127)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116850206..116882290)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator family member 6 Neighboring gene trafficking protein particle complex subunit 3L Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene RWD domain containing 1 Neighboring gene radial spoke head component 4A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ32239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcium homeostasis modulator protein 4
Names
family with sequence similarity 26 member D
protein FAM26D

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256887.3NP_001243816.1  calcium homeostasis modulator protein 4 isoform a

    See identical proteins and their annotated locations for NP_001243816.1

    Status: VALIDATED

    Source sequence(s)
    AK056801, AK300309, AL121953, BC057769
    Consensus CDS
    CCDS59032.1
    UniProtKB/Swiss-Prot
    Q5JW98
    Related
    ENSP00000385836.1, ENST00000405399.5
    Conserved Domains (1) summary
    pfam14798
    Location:8114
    Ca_hom_mod; Calcium homeostasis modulator
  2. NM_001256888.3NP_001243817.1  calcium homeostasis modulator protein 4 isoform b

    See identical proteins and their annotated locations for NP_001243817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK056801, AK300309, AL121953
    Consensus CDS
    CCDS59031.1
    UniProtKB/Swiss-Prot
    Q5JW98
    Related
    ENSP00000487169.1, ENST00000628083.1
    Conserved Domains (1) summary
    pfam14798
    Location:14113
    Ca_hom_mod; Calcium homeostasis modulator
  3. NM_001256889.3NP_001243818.1  calcium homeostasis modulator protein 4 isoform c precursor

    See identical proteins and their annotated locations for NP_001243818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AK056801, AK300309, AL121953, DA855717
    Consensus CDS
    CCDS5109.1
    UniProtKB/Swiss-Prot
    Q5JW98
    Related
    ENSP00000409556.1, ENST00000452373.5
    Conserved Domains (1) summary
    pfam14798
    Location:171
    Ca_hom_mod; Calcium homeostasis modulator
  4. NM_001366078.2NP_001353007.1  calcium homeostasis modulator protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL121953
    Related
    ENSP00000357585.3, ENST00000368596.3
    Conserved Domains (1) summary
    pfam14798
    Location:8257
    Ca_hom_mod; Calcium homeostasis modulator
  5. NM_153036.5NP_694581.1  calcium homeostasis modulator protein 4 isoform c precursor

    See identical proteins and their annotated locations for NP_694581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AK056801, AL121953, AY358252
    Consensus CDS
    CCDS5109.1
    UniProtKB/Swiss-Prot
    Q5JW98
    Related
    ENSP00000357586.2, ENST00000368597.6
    Conserved Domains (1) summary
    pfam14798
    Location:171
    Ca_hom_mod; Calcium homeostasis modulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    116529021..116561127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535562.2XP_011533864.1  calcium homeostasis modulator protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011533864.1

    Conserved Domains (1) summary
    pfam14798
    Location:25128
    Ca_hom_mod; Calcium homeostasis modulator
  2. XM_011535560.2XP_011533862.1  calcium homeostasis modulator protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011533862.1

    Conserved Domains (1) summary
    pfam14798
    Location:25128
    Ca_hom_mod; Calcium homeostasis modulator
  3. XM_017010390.1XP_016865879.1  calcium homeostasis modulator protein 4 isoform X2

  4. XM_017010391.1XP_016865880.1  calcium homeostasis modulator protein 4 isoform X3

  5. XM_011535561.2XP_011533863.1  calcium homeostasis modulator protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011533863.1

    Conserved Domains (1) summary
    pfam14798
    Location:25128
    Ca_hom_mod; Calcium homeostasis modulator
  6. XM_017010392.1XP_016865881.1  calcium homeostasis modulator protein 4 isoform X4

    Conserved Domains (1) summary
    pfam14798
    Location:25128
    Ca_hom_mod; Calcium homeostasis modulator
  7. XM_011535563.2XP_011533865.1  calcium homeostasis modulator protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011533865.1

    Conserved Domains (1) summary
    pfam14798
    Location:25128
    Ca_hom_mod; Calcium homeostasis modulator
  8. XM_011535564.1XP_011533866.1  calcium homeostasis modulator protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011533866.1

    Conserved Domains (1) summary
    pfam14798
    Location:25128
    Ca_hom_mod; Calcium homeostasis modulator
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