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MICU2 mitochondrial calcium uptake 2 [ Homo sapiens (human) ]

Gene ID: 221154, updated on 14-Aug-2021

Summary

Official Symbol
MICU2provided by HGNC
Official Full Name
mitochondrial calcium uptake 2provided by HGNC
Primary source
HGNC:HGNC:31830
See related
Ensembl:ENSG00000165487 MIM:610632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFHA1; 1110008L20Rik
Expression
Ubiquitous expression in kidney (RPKM 25.3), adrenal (RPKM 19.4) and 25 other tissues See more
Orthologs
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Genomic context

See MICU2 in Genome Data Viewer
Location:
13q12.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (21492691..21604205, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (22066830..22178309, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene mitochondrial intermediate peptidase pseudogene 3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 20 Neighboring gene H2B histone pseudogene 6 Neighboring gene farnesyltransferase, CAAX box, alpha pseudogene 2 Neighboring gene RNA, U6 small nuclear 59, pseudogene Neighboring gene uncharacterized LOC107984582 Neighboring gene ribosomal protein S7 pseudogene 10 Neighboring gene fibroblast growth factor 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic determinants of P wave duration and PR segment.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25016, FLJ34588

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of uniplex complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium uptake protein 2, mitochondrial
Names
EF hand domain family A1
EF hand domain family, member A1
EF-hand domain-containing family member A1
Smhs2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152726.3NP_689939.1  calcium uptake protein 2, mitochondrial

    See identical proteins and their annotated locations for NP_689939.1

    Status: VALIDATED

    Source sequence(s)
    AL138680, BC031089, BQ438851
    Consensus CDS
    CCDS9297.1
    UniProtKB/Swiss-Prot
    Q8IYU8
    UniProtKB/TrEMBL
    A0A0S2Z6V5
    Related
    ENSP00000371811.4, ENST00000382374.9
    Conserved Domains (1) summary
    cd16174
    Location:176395
    EFh_MICU2; EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    21492691..21604205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020433.1XP_016875922.1  calcium uptake protein 2, mitochondrial isoform X1

RNA

  1. XR_001749501.2 RNA Sequence

  2. XR_429214.4 RNA Sequence

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