U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tsn translin [ Mus musculus (house mouse) ]

Gene ID: 22099, updated on 5-Mar-2024

Summary

Official Symbol
Tsnprovided by MGI
Official Full Name
translinprovided by MGI
Primary source
MGI:MGI:109263
See related
Ensembl:ENSMUSG00000026374 AllianceGenome:MGI:109263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3PO; TB-RBP; 2610034C24Rik
Summary
Enables mRNA binding activity. Predicted to be involved in RNA metabolic process. Located in cytoplasm and nucleus. Orthologous to human TSN (translin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 26.5), CNS E14 (RPKM 24.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tsn in Genome Data Viewer
Location:
1 E2.3; 1 52.14 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118226244..118239463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118298514..118311461, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene retinoblastoma binding protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01974 Neighboring gene predicted gene, 53580 Neighboring gene STARR-seq mESC enhancer starr_01975 Neighboring gene STARR-positive B cell enhancer ABC_E5790 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 Neighboring gene predicted gene 28867

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in siRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of endoribonuclease complex ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translin
Names
component 3 of promoter of RISC
testis/brain-RNA-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011650.4NP_035780.1  translin

    See identical proteins and their annotated locations for NP_035780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding variant.
    Source sequence(s)
    AC121531, CX243508
    Consensus CDS
    CCDS35690.1
    UniProtKB/Swiss-Prot
    Q62348
    UniProtKB/TrEMBL
    Q545E6
    Related
    ENSMUSP00000027623.8, ENSMUST00000027623.9
    Conserved Domains (1) summary
    cd14819
    Location:10216
    Translin; also known as TB-RBP (testis brain RNA-binding protein)

RNA

  1. NR_153836.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks the translational start codon and a believable ORF, compared to variant 1.
    Source sequence(s)
    AC121531

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    118226244..118239463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252998.2XP_030108858.1  translin isoform X1

    Conserved Domains (1) summary
    cl00957
    Location:10126
    Translin-like; Translin and translin-associated factor-X (TRAX)