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FAM13C family with sequence similarity 13 member C [ Homo sapiens (human) ]

Gene ID: 220965, updated on 5-Aug-2018

Summary

Official Symbol
FAM13Cprovided by HGNC
Official Full Name
family with sequence similarity 13 member Cprovided by HGNC
Primary source
HGNC:HGNC:19371
See related
Ensembl:ENSG00000148541 Vega:OTTHUMG00000018277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM13C1
Expression
Broad expression in brain (RPKM 29.0), adrenal (RPKM 16.8) and 21 other tissues See more
Orthologs

Genomic context

See FAM13C in Genome Data Viewer
Location:
10q21.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (59245933..59363181, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61005889..61122661, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 6 pseudogene 1 Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein like Neighboring gene cervical carcinoma expressed PCNA regulatory lncRNA Neighboring gene uncharacterized LOC102724778 Neighboring gene uncharacterized LOC107984235 Neighboring gene mitochondrial ribosomal protein L50 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
protein FAM13C
Names
family with sequence similarity 13, member C1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053188.1 RefSeqGene

    Range
    5593..122059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001971.2NP_001001971.1  protein FAM13C isoform 2

    See identical proteins and their annotated locations for NP_001001971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AI453702, AK289796, BC064431, BM677909
    Consensus CDS
    CCDS31207.1
    UniProtKB/Swiss-Prot
    Q8NE31
    UniProtKB/TrEMBL
    A8K181
    Related
    ENSP00000481830.1, OTTHUMP00000276239, ENST00000611933.4, OTTHUMT00000358922
    Conserved Domains (1) summary
    cl08298
    Location:291355
    NAP; Nucleosome assembly protein (NAP)
  2. NM_001143773.1NP_001137245.1  protein FAM13C isoform 3

    See identical proteins and their annotated locations for NP_001137245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 7, and 8 all encode the same isoform (3).
    Source sequence(s)
    AI453702, AK289796, AK299924, BC064431, BM677909
    Consensus CDS
    CCDS44406.1
    UniProtKB/Swiss-Prot
    Q8NE31
    UniProtKB/TrEMBL
    A8K181, B4DSU7
    Related
    ENSP00000423896.1, OTTHUMP00000217375, ENST00000468840.6, OTTHUMT00000358921
  3. NM_001166698.1NP_001160170.1  protein FAM13C isoform 4

    See identical proteins and their annotated locations for NP_001160170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4, 9, and 10 all encode the same isoform (4).
    Source sequence(s)
    AK316542, BM677909, BM714192, BP394664, DA188937
    Consensus CDS
    CCDS53538.1
    UniProtKB/Swiss-Prot
    Q8NE31
    Related
    ENSP00000480677.1, ENST00000618427.4
    Conserved Domains (1) summary
    COG3351
    Location:303384
    FlaD; Archaellum component FlaD/FlaE [Cell motility]
  4. NM_001347840.1NP_001334769.1  protein FAM13C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 3 and 8, encodes isoform 3.
    Source sequence(s)
    AC025038, AK316542, AL355474
    Consensus CDS
    CCDS44406.1
    UniProtKB/Swiss-Prot
    Q8NE31
  5. NM_001347842.1NP_001334771.1  protein FAM13C isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 4 and 10, encodes isoform 4.
    Source sequence(s)
    AC025038, AK316542, AL355474
    Consensus CDS
    CCDS53538.1
    UniProtKB/Swiss-Prot
    Q8NE31
  6. NM_001347843.1NP_001334772.1  protein FAM13C isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC025038, AK316542, AL355474, KF459662
    UniProtKB/Swiss-Prot
    Q8NE31
  7. NM_001347844.1NP_001334773.1  protein FAM13C isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 4 and 9, encodes isoform 4.
    Source sequence(s)
    AC025038, AK316542, AL355474, KF459662
    Consensus CDS
    CCDS53538.1
    UniProtKB/Swiss-Prot
    Q8NE31
  8. NM_001347845.1NP_001334774.1  protein FAM13C isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC025038, AK316542, AL355474, KF459662
    UniProtKB/Swiss-Prot
    Q8NE31
  9. NM_001347846.1NP_001334775.1  protein FAM13C isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform 8.
    Source sequence(s)
    AC025038, AL355474, KF459662
  10. NM_001347847.1NP_001334776.1  protein FAM13C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 3 and 7, encodes isoform 3.
    Source sequence(s)
    AC025038, AK316542, AL355474, KF459662
    Consensus CDS
    CCDS44406.1
    UniProtKB/Swiss-Prot
    Q8NE31
  11. NM_001347848.1NP_001334777.1  protein FAM13C isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform 7.
    Source sequence(s)
    AC025038, AK316542, AL355474, KF459662
    UniProtKB/Swiss-Prot
    Q8NE31
  12. NM_001347849.1NP_001334778.1  protein FAM13C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC025038, AL355474, KF459662
  13. NM_001347850.1NP_001334779.1  protein FAM13C isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform 7.
    Source sequence(s)
    AC025038, AK316542, AL355474, KF459662
    UniProtKB/Swiss-Prot
    Q8NE31
  14. NM_001347851.1NP_001334780.1  protein FAM13C isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform 8.
    Source sequence(s)
    AC025038, AL355474, KF459662
  15. NM_001347852.1NP_001334781.1  protein FAM13C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK294805, AL355474, KF459662
    Consensus CDS
    CCDS86096.1
    UniProtKB/TrEMBL
    B7Z2K3
    Related
    ENSP00000392302.2, ENST00000435852.6
  16. NM_198215.3NP_937858.2  protein FAM13C isoform 1

    See identical proteins and their annotated locations for NP_937858.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI453702, AK289796, BC064431, BM677909
    Consensus CDS
    CCDS7255.1
    UniProtKB/Swiss-Prot
    Q8NE31
    UniProtKB/TrEMBL
    A8K181
    Related
    ENSP00000481854.1, OTTHUMP00000276235, ENST00000618804.4, OTTHUMT00000048162

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    59245933..59363181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015889.1XP_016871378.1  protein FAM13C isoform X3

    UniProtKB/Swiss-Prot
    Q8NE31
    Conserved Domains (1) summary
    COG3351
    Location:303384
    FlaD; Archaellum component FlaD/FlaE [Cell motility]
  2. XM_006717702.3XP_006717765.1  protein FAM13C isoform X2

    See identical proteins and their annotated locations for XP_006717765.1

    UniProtKB/Swiss-Prot
    Q8NE31
  3. XM_017015891.1XP_016871380.1  protein FAM13C isoform X6

  4. XM_017015886.1XP_016871375.1  protein FAM13C isoform X3

    UniProtKB/Swiss-Prot
    Q8NE31
    Conserved Domains (1) summary
    COG3351
    Location:303384
    FlaD; Archaellum component FlaD/FlaE [Cell motility]
  5. XM_005269619.4XP_005269676.2  protein FAM13C isoform X5

    Conserved Domains (1) summary
    cl08298
    Location:291352
    NAP; Nucleosome assembly protein (NAP)
  6. XM_005269618.4XP_005269675.2  protein FAM13C isoform X1

    Related
    ENSP00000484625.1, OTTHUMP00000276237, ENST00000621119.4, OTTHUMT00000048165
    Conserved Domains (1) summary
    COG3351
    Location:386467
    FlaD; Archaellum component FlaD/FlaE [Cell motility]
  7. XM_024447879.1XP_024303647.1  protein FAM13C isoform X7

  8. XM_011539490.2XP_011537792.1  protein FAM13C isoform X4

    See identical proteins and their annotated locations for XP_011537792.1

  9. XM_011539491.2XP_011537793.1  protein FAM13C isoform X4

    See identical proteins and their annotated locations for XP_011537793.1

  10. XM_024447880.1XP_024303648.1  protein FAM13C isoform X8

  11. XM_024447881.1XP_024303649.1  protein FAM13C isoform X9

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