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Trp63 transformation related protein 63 [ Mus musculus (house mouse) ]

Gene ID: 22061, updated on 24-Feb-2026
Official Symbol
Trp63provided by MGI
Official Full Name
transformation related protein 63provided by MGI
Primary source
MGI:MGI:1330810
See related
Ensembl:ENSMUSG00000022510 AllianceGenome:MGI:1330810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ket; P63; P73l; Tp63; P51/P63; Trp53rp1
Summary
This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Expression
Biased expression in bladder adult (RPKM 13.9), genital fat pad adult (RPKM 5.5) and 5 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Trp63 in Genome Data Viewer
Location:
16 B1; 16 17.37 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (25502513..25710842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (25683763..25892088)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40474 Neighboring gene STARR-seq mESC enhancer starr_40475 Neighboring gene STARR-seq mESC enhancer starr_40477 Neighboring gene STARR-seq mESC enhancer starr_40478 Neighboring gene STARR-seq mESC enhancer starr_40479 Neighboring gene UPF0568 protein C14orf166 homolog Neighboring gene predicted gene, 24928 Neighboring gene C15 enhancer in intron of tumor protein p63 gene Neighboring gene STARR-seq mESC enhancer starr_40480 Neighboring gene STARR-seq mESC enhancer starr_40481 Neighboring gene DeltaNp63 promoter of tumor protein p63 Neighboring gene STARR-seq mESC enhancer starr_40482 Neighboring gene C40 intronic enhancer of tumor protein p63 gene Neighboring gene predicted gene 4524 Neighboring gene VISTA enhancer mm1095 Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene VISTA enhancer mm1097 Neighboring gene expressed sequence AU015336

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Brdm2 - an aberrant hypomorphic p63 allele. Talos F, et al. Cell Death Differ, 2010 Jan. PMID 20161489, Free PMC Article
  2. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Koster MI, et al. Cancer Res, 2006 Apr 15. PMID 16618715
  3. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Sommer M, et al. Cell Cycle, 2006 Sep. PMID 16940753
  4. The role of p63 in germ cell apoptosis in the developing testis. Petre-Lazar B, et al. J Cell Physiol, 2007 Jan. PMID 16998800
  5. ΔNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis. Eyermann CE, et al. J Invest Dermatol, 2024 Jan. PMID 37543242

See all (663) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice.
    Title: Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice.
  2. DeltaNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis.
    Title: ΔNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis.
  3. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-gamma signaling in squamous cancer.
    Title: Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.
  4. Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63.
    Title: Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63.
  5. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.
    Title: Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.
  6. A TP63 mutation identified in a Han Chinese family with ectodermal dysplasia.
    Title: A TP63 mutation identified in a Han Chinese family with ectodermal dysplasia.
  7. TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.
    Title: TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.
  8. TAp63 determines the fate of oocytes against DNA damage.
    Title: TAp63 determines the fate of oocytes against DNA damage.
  9. DeltaNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland.
    Title: ΔNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland.
  10. The role of p63 in embryonic external genitalia outgrowth in mice.
    Title: The role of p63 in embryonic external genitalia outgrowth in mice.
Submit: New GeneRIF Correction See all GeneRIFs (194)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC115972

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MDM2/MDM4 family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables WW domain binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within keratinocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tumor protein 63

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127259.1 → NP_001120731.1  tumor protein 63 isoform a

    See identical proteins and their annotated locations for NP_001120731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also known as TAp63alpha).
    Source sequence(s)
    AF075436, AK138305, BC090649
    Consensus CDS
    CCDS49809.1
    UniProtKB/Swiss-Prot
    O88897, O88898, O88899, O89097, Q8C826, Q9QWY9, Q9QWZ0
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000110965.3, ENSMUST00000115310.9
    Conserved Domains (4) summary
    cd09572
    Location:543 → 607
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam00870
    Location:163 → 358
    P53; P53 DNA-binding domain
    pfam07710
    Location:392 → 431
    P53_tetramer; P53 tetramerisation motif
    pfam08430
    Location:452 → 535
    Forkhead_N; Forkhead N-terminal region

  2. NM_001127260.1 → NP_001120732.1  tumor protein 63 isoform b

    See identical proteins and their annotated locations for NP_001120732.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (b, also known as TAp63beta) has a shorter and different C-terminus, as compared to isoform a.
    Source sequence(s)
    AF075435, AK138305, BC090649
    Consensus CDS
    CCDS49810.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000067005.6, ENSMUST00000065523.12
    Conserved Domains (2) summary
    cd08367
    Location:177 → 358
    P53; P53 DNA-binding domain
    pfam07710
    Location:392 → 428
    P53_tetramer; P53 tetramerisation motif

  3. NM_001127261.1 → NP_001120733.1  tumor protein 63 isoform c

    See identical proteins and their annotated locations for NP_001120733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal 12 nt segment and several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (c, also known as TAp63gamma) lacks internal 4 aa and has a shorter and different C-terminus, as compared to isoform a.
    Source sequence(s)
    AF075434, AK138305, AK140023, BC092537
    Consensus CDS
    CCDS49808.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q569E5
    Related
    ENSMUSP00000110963.3, ENSMUST00000115308.9
    Conserved Domains (2) summary
    cd08367
    Location:177 → 358
    P53; P53 DNA-binding domain
    pfam07710
    Location:388 → 424
    P53_tetramer; P53 tetramerisation motif

  4. NM_001127262.1 → NP_001120734.1  tumor protein 63 isoform f

    See identical proteins and their annotated locations for NP_001120734.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is an alternate promoter product; it lacks several 5' exons and an internal exon in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (f, also known as DNp63beta) has shorter and different N- and C-termini, as compared to isoform a.
    Source sequence(s)
    AF075438, AK048623, BC090649
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q5CZX0
    Conserved Domains (2) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain
    pfam07710
    Location:298 → 334
    P53_tetramer; P53 tetramerisation motif

  5. NM_001127263.1 → NP_001120735.1  tumor protein 63 isoform g

    See identical proteins and their annotated locations for NP_001120735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is an alternate promoter product; it lacks several 5' and 3' exons, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (g, also known as DNp63gamma) has shorter and different N- and C-termini, as compared to isoform a.
    Source sequence(s)
    AK140023, BC092537
    Consensus CDS
    CCDS49812.1
    UniProtKB/TrEMBL
    Q569E5
    Related
    ENSMUSP00000110960.2, ENSMUST00000115305.2
    Conserved Domains (2) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain
    pfam07710
    Location:298 → 334
    P53_tetramer; P53 tetramerisation motif

  6. NM_001127264.1 → NP_001120736.1  tumor protein 63 isoform e

    See identical proteins and their annotated locations for NP_001120736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is an alternate promoter product; it lacks several 5' exons and an internal 12 nt segment, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (e) has a shorter and different N-terminus, and lacks internal 4 aa, as compared to isoform a.
    Source sequence(s)
    AK048623, AK137253, BC090649
    Consensus CDS
    CCDS49811.1
    UniProtKB/TrEMBL
    Q3UVI3, Q5CZX0
    Related
    ENSMUSP00000110961.2, ENSMUST00000115306.8
    Conserved Domains (3) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain
    cd09572
    Location:445 → 509
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam07710
    Location:294 → 330
    P53_tetramer; P53 tetramerisation motif

  7. NM_001127265.1 → NP_001120737.1  tumor protein 63 isoform h

    See identical proteins and their annotated locations for NP_001120737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is an alternate promoter product; it lacks several 5' and 3' exons and an internal 12 nt segment, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (h, also known as DNp63gamma) has shorter and different N- and C-termini, and lacks internal 4 aa, as compared to isoform a.
    Source sequence(s)
    AF075437, AK048623, AK140023, BC092537
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q569E5
    Conserved Domains (2) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain
    pfam07710
    Location:294 → 330
    P53_tetramer; P53 tetramerisation motif

  8. NM_001427037.1 → NP_001413966.1  tumor protein 63 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC109213, AC113020
    UniProtKB/TrEMBL
    Q5CZX0

  9. NM_011641.2 → NP_035771.1  tumor protein 63 isoform d

    See identical proteins and their annotated locations for NP_035771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is an alternate promoter product; it lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (d, also known as DNp63alpha) has a shorter and different N-terminus, as compared to isoform a.
    Source sequence(s)
    AF075439, AK048623, BC090649
    Consensus CDS
    CCDS28085.1
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000038117.7, ENSMUST00000040231.13
    Conserved Domains (3) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain
    cd09572
    Location:449 → 513
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam07710
    Location:298 → 334
    P53_tetramer; P53 tetramerisation motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    25502513..25710842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522002.1 → XP_006522065.1  tumor protein 63 isoform X3

    Conserved Domains (2) summary
    cd08367
    Location:177 → 358
    P53; P53 DNA-binding domain
    pfam07710
    Location:392 → 428
    P53_tetramer; P53 tetramerisation motif

  2. XM_006522001.3 → XP_006522064.1  tumor protein 63 isoform X2

    UniProtKB/TrEMBL
    Q5CZX0
    Conserved Domains (4) summary
    cd08367
    Location:58 → 239
    P53; P53 DNA-binding domain
    cd09572
    Location:424 → 488
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam07710
    Location:273 → 309
    P53_tetramer; P53 tetramerisation motif
    pfam08430
    Location:338 → 415
    Forkhead_N; Forkhead N-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88898.1 GenPept UniProtKB/Swiss-Prot:O88898

Gene LinkOut

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