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LRRC63 leucine rich repeat containing 63 [ Homo sapiens (human) ]

Gene ID: 220416, updated on 25-Jan-2022

Summary

Official Symbol
LRRC63provided by HGNC
Official Full Name
leucine rich repeat containing 63provided by HGNC
Primary source
HGNC:HGNC:34296
See related
Ensembl:ENSG00000173988 AllianceGenome:HGNC:34296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 1.5), prostate (RPKM 0.2) and 3 other tissues See more
Orthologs
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Genomic context

See LRRC63 in Genome Data Viewer
Location:
13q14.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (46211919..46277115)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46786063..46851250)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene RNA, 7SL, cytoplasmic 288, pseudogene Neighboring gene uncharacterized LOC105370192 Neighboring gene uncharacterized LOC107984578 Neighboring gene RN7SK pseudogene 5 Neighboring gene uncharacterized LOC105370194 Neighboring gene ABITRAM pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 563 Neighboring gene rubicon like autophagy enhancer Neighboring gene RNA, U2 small nuclear 6, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • RP11-139H14.4

General protein information

Preferred Names
leucine-rich repeat-containing protein 63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282460.2NP_001269389.1  leucine-rich repeat-containing protein 63

    Status: VALIDATED

    Source sequence(s)
    AL137141, AL139801, BC030276
    Consensus CDS
    CCDS61325.1
    UniProtKB/Swiss-Prot
    Q05C16
    UniProtKB/TrEMBL
    J3KQU2
    Related
    ENSP00000469337.1, ENST00000595396.2
    Conserved Domains (2) summary
    sd00033
    Location:347369
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:393449
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    46211919..46277115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020421.1XP_016875910.1  leucine-rich repeat-containing protein 63 isoform X1

    UniProtKB/TrEMBL
    J3KQU2
    Conserved Domains (2) summary
    sd00033
    Location:347369
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:393449
    LRR_8; Leucine rich repeat
  2. XM_017020429.1XP_016875918.1  leucine-rich repeat-containing protein 63 isoform X11

  3. XM_017020430.1XP_016875919.1  leucine-rich repeat-containing protein 63 isoform X11

  4. XM_017020422.1XP_016875911.1  leucine-rich repeat-containing protein 63 isoform X2

  5. XM_017020431.1XP_016875920.1  leucine-rich repeat-containing protein 63 isoform X12

  6. XM_011534993.1XP_011533295.1  leucine-rich repeat-containing protein 63 isoform X13

  7. XM_017020428.1XP_016875917.1  leucine-rich repeat-containing protein 63 isoform X10

  8. XM_011534992.2XP_011533294.1  leucine-rich repeat-containing protein 63 isoform X10

    Related
    ENSP00000502820.1, ENST00000674837.1
  9. XM_017020424.1XP_016875913.1  leucine-rich repeat-containing protein 63 isoform X4

    Related
    ENSP00000501680.1, ENST00000675195.1
  10. XM_011534989.2XP_011533291.1  leucine-rich repeat-containing protein 63 isoform X8

    Related
    ENSP00000501788.1, ENST00000676025.1
  11. XM_017020425.1XP_016875914.1  leucine-rich repeat-containing protein 63 isoform X5

    Related
    ENSP00000502368.1, ENST00000674850.1
  12. XM_017020426.1XP_016875915.1  leucine-rich repeat-containing protein 63 isoform X6

    Related
    ENSP00000502389.1, ENST00000675095.1
  13. XM_017020427.1XP_016875916.1  leucine-rich repeat-containing protein 63 isoform X7

  14. XM_011534990.2XP_011533292.1  leucine-rich repeat-containing protein 63 isoform X9

  15. XM_017020423.1XP_016875912.1  leucine-rich repeat-containing protein 63 isoform X3

RNA

  1. XR_001749493.1 RNA Sequence

  2. XR_941519.2 RNA Sequence

  3. XR_001749492.1 RNA Sequence

  4. XR_001749498.1 RNA Sequence

    Related
    ENST00000674570.1
  5. XR_941518.2 RNA Sequence

  6. XR_941520.2 RNA Sequence

  7. XR_941517.2 RNA Sequence

  8. XR_001749496.1 RNA Sequence

  9. XR_001749494.1 RNA Sequence

  10. XR_001749497.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024609.1: Suppressed sequence

    Description
    NM_001024609.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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