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CBY2 chibby family member 2 [ Homo sapiens (human) ]

Gene ID: 220082, updated on 21-Dec-2019

Summary

Official Symbol
CBY2provided by HGNC
Official Full Name
chibby family member 2provided by HGNC
Primary source
HGNC:HGNC:30720
See related
Ensembl:ENSG00000174015 MIM:618614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NURIT; SPERT
Expression
Restricted expression toward testis (RPKM 11.6) See more
Orthologs

Genomic context

See CBY2 in Genome Data Viewer
Location:
13q14.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (45701030..45714559)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46276446..46288694)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 4I1 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 1055 Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 4 Neighboring gene siah E3 ubiquitin protein ligase family member 3 Neighboring gene uncharacterized LOC105370191

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT ciliary transition zone assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
NOT centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
spermatid-associated protein
Names
novel leucine zipper testicular protein
protein chibby homolog 2
spermatid associated
spermatid flower-like structure protein
testicular tissue protein Li 182
testis-specific leucine zipper protein nurit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286341.2NP_001273270.1  spermatid-associated protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC027609, HY007057, HY026582
    UniProtKB/Swiss-Prot
    Q8NA61
    Conserved Domains (2) summary
    cd07429
    Location:50165
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:278400
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
  2. NM_001286342.1NP_001273271.1  spermatid-associated protein isoform 3

    See identical proteins and their annotated locations for NP_001273271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC027609, HY016268
    Consensus CDS
    CCDS66540.1
    UniProtKB/Swiss-Prot
    Q8NA61
    Related
    ENSP00000480148.1, ENST00000610924.1
    Conserved Domains (2) summary
    cd07429
    Location:41156
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:268391
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
  3. NM_152719.3NP_689932.1  spermatid-associated protein isoform 1

    See identical proteins and their annotated locations for NP_689932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK093129, BC027609, HY017873
    Consensus CDS
    CCDS9399.1
    UniProtKB/Swiss-Prot
    Q8NA61
    UniProtKB/TrEMBL
    A0A140VJV5
    Related
    ENSP00000309189.1, ENST00000310521.6
    Conserved Domains (2) summary
    cd07429
    Location:77192
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:305427
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    45701030..45714559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534971.2XP_011533273.1  spermatid-associated protein isoform X1

    Conserved Domains (2) summary
    cd07429
    Location:104219
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:332454
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
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