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DDIAS DNA damage induced apoptosis suppressor [ Homo sapiens (human) ]

Gene ID: 220042, updated on 22-Jun-2021

Summary

Official Symbol
DDIASprovided by HGNC
Official Full Name
DNA damage induced apoptosis suppressorprovided by HGNC
Primary source
HGNC:HGNC:26351
See related
Ensembl:ENSG00000165490 MIM:618045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
noxin; C11orf82
Expression
Broad expression in testis (RPKM 5.9), lymph node (RPKM 1.9) and 14 other tissues See more
Orthologs
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Genomic context

See DDIAS in Genome Data Viewer
Location:
11q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (82901735..82934659)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82612778..82645701)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene prolylcarboxypeptidase Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene ribosomal protein L7a pseudogene 54 Neighboring gene RAB30, member RAS oncogene family Neighboring gene small nucleolar RNA, H/ACA box 70E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13936, FLJ25416, FLJ38838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA damage-induced apoptosis suppressor protein
Names
nitric oxide-inducible gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363481.2NP_001350410.1  DNA damage-induced apoptosis suppressor protein

    Status: VALIDATED

    Source sequence(s)
    AP001646
    Consensus CDS
    CCDS8263.1
    Conserved Domains (1) summary
    cl09930
    Location:8130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
  2. NM_145018.4NP_659455.3  DNA damage-induced apoptosis suppressor protein

    See identical proteins and their annotated locations for NP_659455.3

    Status: VALIDATED

    Source sequence(s)
    AA477171, AK096157, BC039268, DB023053, DB454086
    Consensus CDS
    CCDS8263.1
    UniProtKB/Swiss-Prot
    Q8IXT1
    Related
    ENSP00000435421.1, ENST00000533655.6
    Conserved Domains (1) summary
    cl09930
    Location:8130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    82901735..82934659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448400.1XP_024304168.1  DNA damage-induced apoptosis suppressor protein isoform X1

    Conserved Domains (1) summary
    cl09930
    Location:8130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
  2. XM_011544836.2XP_011543138.1  DNA damage-induced apoptosis suppressor protein isoform X1

    See identical proteins and their annotated locations for XP_011543138.1

    UniProtKB/Swiss-Prot
    Q8IXT1
    Related
    ENSP00000329930.4, ENST00000329143.4
    Conserved Domains (1) summary
    cl09930
    Location:8130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
  3. XM_011544837.1XP_011543139.1  DNA damage-induced apoptosis suppressor protein isoform X2

    See identical proteins and their annotated locations for XP_011543139.1

    UniProtKB/TrEMBL
    B4DMA1
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