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OR8B12 olfactory receptor family 8 subfamily B member 12 [ Homo sapiens (human) ]

Gene ID: 219858, updated on 11-Jun-2021

Summary

Official Symbol
OR8B12provided by HGNC
Official Full Name
olfactory receptor family 8 subfamily B member 12provided by HGNC
Primary source
HGNC:HGNC:15307
See related
Ensembl:ENSG00000170953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-317
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR8B12 in Genome Data Viewer
Location:
11q24.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (124542722..124543654, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124412618..124413550, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 8 subfamily B member 3 pseudogene Neighboring gene olfactory receptor family 8 subfamily A member 1 Neighboring gene olfactory receptor family 8 subfamily Q member 1 pseudogene

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 8B12
Names
olfactory receptor OR11-317

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005195.1NP_001005195.1  olfactory receptor 8B12

    See identical proteins and their annotated locations for NP_001005195.1

    Status: VALIDATED

    Source sequence(s)
    AB065834
    Consensus CDS
    CCDS31711.1
    UniProtKB/Swiss-Prot
    Q8NGG6
    UniProtKB/TrEMBL
    A0A126GWS7
    Related
    ENSP00000307159.2, ENST00000306842.3
    Conserved Domains (2) summary
    pfam00001
    Location:40289
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:30307
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    124542722..124543654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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