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Tpd52 tumor protein D52 [ Mus musculus (house mouse) ]

Gene ID: 21985, updated on 2-Nov-2024

Summary

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Official Symbol
Tpd52provided by MGI
Official Full Name
tumor protein D52provided by MGI
Primary source
MGI:MGI:107749
See related
Ensembl:ENSMUSG00000027506 AllianceGenome:MGI:107749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mD52
Summary
Enables protein homodimerization activity. Acts upstream of or within positive regulation of cell population proliferation. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 34.0), colon adult (RPKM 25.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tpd52 in Genome Data Viewer
Location:
3 A1; 3 2.23 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (8991590..9069824, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (8926530..9005393, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene STARR-positive B cell enhancer mm9_chr3:8916344-8916645 Neighboring gene predicted gene, 52600 Neighboring gene STARR-seq mESC enhancer starr_06865 Neighboring gene predicted gene, 52601 Neighboring gene STARR-seq mESC enhancer starr_06870 Neighboring gene STARR-seq mESC enhancer starr_06875 Neighboring gene STARR-positive B cell enhancer ABC_E7899 Neighboring gene STARR-seq mESC enhancer starr_06879 Neighboring gene STARR-seq mESC enhancer starr_06880 Neighboring gene STARR-seq mESC enhancer starr_06881 Neighboring gene predicted gene, 46832 Neighboring gene predicted gene, 54188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The tumor protein D52 family: many pieces, many puzzles. Boutros R, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555543
  2. Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes. Ito C, et al. Biomed Res Int, 2017. PMID 28798933, Free PMC Article
  3. Induction of tumorigenesis and metastasis by the murine orthologue of tumor protein D52. Lewis JD, et al. Mol Cancer Res, 2007 Feb. PMID 17314271
  4. TPD52 expression increases neutral lipid storage within cultured cells. Kamili A, et al. J Cell Sci, 2015 Sep 1. PMID 26183179, Free PMC Article
  5. Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene? Byrne JA, et al. Tumour Biol, 2014 Aug. PMID 24798974

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
tumor protein D52
NP_001020432.1
NP_001020433.1
NP_001020434.1
NP_001020435.1
NP_001344001.1
NP_001344002.1
NP_001344003.1
NP_033438.1
XP_006530128.1
XP_006530129.1
XP_006530130.1
XP_006530131.1
XP_006530134.1
XP_011246444.1
XP_011246445.1
XP_011246446.1
XP_011246447.1
XP_030108413.1
XP_036018910.1
XP_036018911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025261.3 → NP_001020432.1  tumor protein D52 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Consensus CDS
    CCDS38387.1
    UniProtKB/TrEMBL
    F8WHQ1
    Related
    ENSMUSP00000091943.5, ENSMUST00000094381.11
    Conserved Domains (1) summary
    pfam04201
    Location:51 → 232
    TPD52; Tumour protein D52 family

  2. NM_001025262.3 → NP_001020433.1  tumor protein D52 isoform 2

    See identical proteins and their annotated locations for NP_001020433.1

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Consensus CDS
    CCDS38386.1
    UniProtKB/Swiss-Prot
    Q545M5, Q62393, Q8CCU1, Q8K564, Q99KP8
    Related
    ENSMUSP00000088913.6, ENSMUST00000091354.12
    Conserved Domains (1) summary
    pfam04201
    Location:51 → 209
    TPD52; Tumour protein D52 family

  3. NM_001025263.3 → NP_001020434.1  tumor protein D52 isoform 3

    See identical proteins and their annotated locations for NP_001020434.1

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Consensus CDS
    CCDS38384.1
    UniProtKB/TrEMBL
    D3Z125
    Related
    ENSMUSP00000088914.6, ENSMUST00000091355.12
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 184
    TPD52; Tumour protein D52 family

  4. NM_001025264.3 → NP_001020435.1  tumor protein D52 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Consensus CDS
    CCDS38385.1
    UniProtKB/TrEMBL
    D3Z125, E9PUA7
    Related
    ENSMUSP00000066826.8, ENSMUST00000063496.14
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 179
    TPD52; Tumour protein D52 family

  5. NM_001357072.1 → NP_001344001.1  tumor protein D52 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Conserved Domains (1) summary
    pfam04201
    Location:152 → 301
    TPD52; tumor protein D52 family

  6. NM_001357073.1 → NP_001344002.1  tumor protein D52 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Conserved Domains (1) summary
    pfam04201
    Location:108 → 289
    TPD52; tumor protein D52 family

  7. NM_001357074.2 → NP_001344003.1  tumor protein D52 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    UniProtKB/TrEMBL
    D3Z125
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 193
    TPD52; tumor protein D52 family

  8. NM_001428700.1 → NP_001415629.1  tumor protein D52 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056

  9. NM_001428701.1 → NP_001415630.1  tumor protein D52 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056

  10. NM_001428702.1 → NP_001415631.1  tumor protein D52 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056

  11. NM_001428703.1 → NP_001415632.1  tumor protein D52 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056

  12. NM_001428705.1 → NP_001415634.1  tumor protein D52 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056

  13. NM_009412.4 → NP_033438.1  tumor protein D52 isoform 5

    See identical proteins and their annotated locations for NP_033438.1

    Status: VALIDATED

    Source sequence(s)
    AC133935, AC161056
    Consensus CDS
    CCDS50860.1
    UniProtKB/TrEMBL
    D3Z125
    Related
    ENSMUSP00000112830.2, ENSMUST00000120143.8
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 170
    TPD52; Tumour protein D52 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    8991590..9069824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252553.2 → XP_030108413.1  tumor protein D52 isoform X9

    Related
    ENSMUSP00000119899.2, ENSMUST00000134788.8
    Conserved Domains (1) summary
    pfam04201
    Location:49 → 207
    TPD52; tumor protein D52 family

  2. XM_011248144.2 → XP_011246446.1  tumor protein D52 isoform X3

    UniProtKB/TrEMBL
    D3Z7X7
    Conserved Domains (1) summary
    pfam04201
    Location:60 → 218
    TPD52; tumor protein D52 family

  3. XM_011248142.2 → XP_011246444.1  tumor protein D52 isoform X1

    UniProtKB/TrEMBL
    D3Z7X7
    Conserved Domains (1) summary
    pfam04201
    Location:60 → 232
    TPD52; tumor protein D52 family

  4. XM_011248143.2 → XP_011246445.1  tumor protein D52 isoform X2

    UniProtKB/TrEMBL
    D3Z7X7
    Conserved Domains (1) summary
    pfam04201
    Location:60 → 227
    TPD52; tumor protein D52 family

  5. XM_006530067.5 → XP_006530130.1  tumor protein D52 isoform X7

    Conserved Domains (1) summary
    pfam04201
    Location:51 → 223
    TPD52; tumor protein D52 family

  6. XM_006530068.5 → XP_006530131.1  tumor protein D52 isoform X8

    Conserved Domains (1) summary
    pfam04201
    Location:51 → 218
    TPD52; tumor protein D52 family

  7. XM_036163017.1 → XP_036018910.1  tumor protein D52 isoform X11

    UniProtKB/TrEMBL
    D3Z637
    Related
    ENSMUSP00000113368.2, ENSMUST00000121038.8
    Conserved Domains (1) summary
    pfam04201
    Location:21 → 161
    TPD52; tumor protein D52 family

  8. XM_006530066.5 → XP_006530129.1  tumor protein D52 isoform X5

    Conserved Domains (1) summary
    pfam04201
    Location:49 → 230
    TPD52; tumor protein D52 family

  9. XM_036163018.1 → XP_036018911.1  tumor protein D52 isoform X12

    Conserved Domains (1) summary
    pfam04201
    Location:12 → 128
    TPD52; tumor protein D52 family

  10. XM_011248145.3 → XP_011246447.1  tumor protein D52 isoform X6

    UniProtKB/TrEMBL
    D3Z7X7
    Conserved Domains (1) summary
    pfam04201
    Location:60 → 176
    TPD52; tumor protein D52 family

  11. XM_006530065.5 → XP_006530128.1  tumor protein D52 isoform X4

    Conserved Domains (1) summary
    pfam04201
    Location:56 → 237
    TPD52; tumor protein D52 family

  12. XM_006530071.3 → XP_006530134.1  tumor protein D52 isoform X10

    UniProtKB/TrEMBL
    D3Z637
    Conserved Domains (1) summary
    pfam04201
    Location:21 → 170
    TPD52; tumor protein D52 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62393.2 GenPept UniProtKB/Swiss-Prot:Q62393

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