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Top3b topoisomerase (DNA) III beta [ Mus musculus (house mouse) ]

Gene ID: 21976, updated on 14-May-2024

Summary

Official Symbol
Top3bprovided by MGI
Official Full Name
topoisomerase (DNA) III betaprovided by MGI
Primary source
MGI:MGI:1333803
See related
Ensembl:ENSMUSG00000022779 AllianceGenome:MGI:1333803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA topoisomerase activity. Acts upstream of or within chromosome segregation. Located in condensed chromosome. Is expressed in liver. Orthologous to human TOP3B (DNA topoisomerase III beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.8), kidney adult (RPKM 15.0) and 28 other tissues See more
Orthologs
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Genomic context

See Top3b in Genome Data Viewer
Location:
16 A3; 16 10.46 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16688587..16710850)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16870722..16892986)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40238 Neighboring gene immunoglobulin lambda-like polypeptide 1 Neighboring gene V-set pre-B cell surrogate light chain 1A Neighboring gene STARR-positive B cell enhancer mm9_chr16:16896457-16896758 Neighboring gene protein phosphatase 1F (PP2C domain containing) Neighboring gene STARR-seq mESC enhancer starr_40239 Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA topological change NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of DNA topoisomerase III-beta-TDRD3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of DNA topoisomerase III-beta-TDRD3 complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA topoisomerase 3-beta-1
Names
DNA topoisomerase III beta-1
Topo III beta
NP_001313505.1
NP_035754.1
XP_006522054.1
XP_006522055.1
XP_006522057.1
XP_006522058.1
XP_006522060.1
XP_017172426.1
XP_030104903.1
XP_030104904.1
XP_030104905.1
XP_036015766.1
XP_036015767.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326576.1NP_001313505.1  DNA topoisomerase 3-beta-1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC166832, AK144709, AW122701
    Consensus CDS
    CCDS27990.1
    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Related
    ENSMUSP00000156132.2, ENSMUST00000232581.2
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  2. NM_011624.3NP_035754.1  DNA topoisomerase 3-beta-1

    See identical proteins and their annotated locations for NP_035754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC166832, AK146475, AW122701, BY035336
    Consensus CDS
    CCDS27990.1
    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Related
    ENSMUSP00000023465.8, ENSMUST00000023465.16
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16688587..16710850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249043.2XP_030104903.1  DNA topoisomerase 3-beta-1 isoform X2

    Conserved Domains (2) summary
    pfam01131
    Location:72485
    Topoisom_bac; DNA topoisomerase
    cl00718
    Location:170
    TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
  2. XM_006521991.5XP_006522054.1  DNA topoisomerase 3-beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006522054.1

    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  3. XM_006521997.4XP_006522060.1  DNA topoisomerase 3-beta-1 isoform X3

    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  4. XM_006521992.5XP_006522055.1  DNA topoisomerase 3-beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006522055.1

    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  5. XM_030249045.2XP_030104905.1  DNA topoisomerase 3-beta-1 isoform X2

    Conserved Domains (2) summary
    pfam01131
    Location:72485
    Topoisom_bac; DNA topoisomerase
    cl00718
    Location:170
    TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
  6. XM_030249044.2XP_030104904.1  DNA topoisomerase 3-beta-1 isoform X2

    Conserved Domains (2) summary
    pfam01131
    Location:72485
    Topoisom_bac; DNA topoisomerase
    cl00718
    Location:170
    TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
  7. XM_036159873.1XP_036015766.1  DNA topoisomerase 3-beta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  8. XM_006521994.4XP_006522057.1  DNA topoisomerase 3-beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006522057.1

    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  9. XM_036159874.1XP_036015767.1  DNA topoisomerase 3-beta-1 isoform X4

    Conserved Domains (1) summary
    cd00186
    Location:10322
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
  10. XM_006521995.4XP_006522058.1  DNA topoisomerase 3-beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006522058.1

    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase
  11. XM_017316937.3XP_017172426.1  DNA topoisomerase 3-beta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z321
    UniProtKB/TrEMBL
    Q3UJF5
    Conserved Domains (2) summary
    cd03362
    Location:3167
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    pfam01131
    Location:169582
    Topoisom_bac; DNA topoisomerase

RNA

  1. XR_001781810.3 RNA Sequence

  2. XR_003951778.2 RNA Sequence

    Related
    ENSMUST00000231278.2