Format

Send to:

Choose Destination

TMEM26 transmembrane protein 26 [ Homo sapiens (human) ]

Gene ID: 219623, updated on 11-Jun-2021

Summary

Official Symbol
TMEM26provided by HGNC
Official Full Name
transmembrane protein 26provided by HGNC
Primary source
HGNC:HGNC:28550
See related
Ensembl:ENSG00000196932 MIM:617803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Broad expression in spleen (RPKM 2.6), endometrium (RPKM 1.8) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM26 in Genome Data Viewer
Location:
10q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (61406642..61453381, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (63166400..63213139, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378323 Neighboring gene Sharpr-MPRA regulatory region 6196 Neighboring gene TMEM26 antisense RNA 1 Neighboring gene ciliary associated calcium binding coiled-coil 1 Neighboring gene CRISPRi-validated cis-regulatory element chr10.1925 Neighboring gene long intergenic non-protein coding RNA 2625

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
GeneReviews: Not available
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
GeneReviews: Not available

General gene information

Homology

Clone Names

  • MGC35010, DKFZp686D09128

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178505.8NP_848600.2  transmembrane protein 26

    See identical proteins and their annotated locations for NP_848600.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.
    Source sequence(s)
    AC068892, AW510476, CR749606
    Consensus CDS
    CCDS41530.1
    UniProtKB/Swiss-Prot
    Q6ZUK4
    Related
    ENSP00000382237.3, ENST00000399298.8
    Conserved Domains (1) summary
    pfam09772
    Location:3303
    Tmem26; Transmembrane protein 26

RNA

  1. NR_134507.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) splices out a portion of the 3' terminal exon found in variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK125611, AW510476, CR749606
  2. NR_134508.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068892, BC042872, CR749606

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    61406642..61453381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539450.2XP_011537752.1  transmembrane protein 26 isoform X1

    See identical proteins and their annotated locations for XP_011537752.1

    Conserved Domains (1) summary
    pfam09772
    Location:3227
    Tmem26; Transmembrane protein 26
  2. XM_011539451.1XP_011537753.1  transmembrane protein 26 isoform X3

    See identical proteins and their annotated locations for XP_011537753.1

    UniProtKB/Swiss-Prot
    Q6ZUK4
    Related
    ENSP00000426071.1, ENST00000488505.2
    Conserved Domains (1) summary
    pfam09772
    Location:3202
    Tmem26; Transmembrane protein 26
  3. XM_017015829.1XP_016871318.1  transmembrane protein 26 isoform X2

Support Center