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Tnnt3 troponin T3, skeletal, fast [ Mus musculus (house mouse) ]

Gene ID: 21957, updated on 5-Mar-2024

Summary

Official Symbol
Tnnt3provided by MGI
Official Full Name
troponin T3, skeletal, fastprovided by MGI
Primary source
MGI:MGI:109550
See related
Ensembl:ENSMUSG00000061723 AllianceGenome:MGI:109550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fTnT
Summary
Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in several processes, including positive regulation of calcium-dependent ATPase activity; regulation of ATPase activity; and sarcomere organization. Predicted to be part of troponin complex. Is expressed in several structures, including diaphragm; eyelid epithelium; lower jaw; musculature; and urinary system. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 50.5), bladder adult (RPKM 9.6) and 4 other tissues See more
Orthologs
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Genomic context

See Tnnt3 in Genome Data Viewer
Location:
7 F5; 7 87.94 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142052530..142069746)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142498771..142516213)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene troponin I, skeletal, fast 2 Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149724284-149724471 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene H19/Igf2 enhancer region Neighboring gene non-coding transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to actin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to tropomyosin binding ISO
Inferred from Sequence Orthology
more info
 
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin C binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables troponin C binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin I binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables troponin I binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of calcium-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin T, fast skeletal muscle
Names
fast skeletal muscle troponin T
fast skeletal muscle troponin T3
skeletal muscle fast-twitch TnT
tnTf

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163664.1NP_001157136.1  troponin T, fast skeletal muscle isoform 1

    See identical proteins and their annotated locations for NP_001157136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI037743, AI173874, AI574395, CK791812, DV049834
    Consensus CDS
    CCDS52452.1
    UniProtKB/TrEMBL
    J3QP61, Z4YNB2
    Related
    ENSMUSP00000136278.2, ENSMUST00000179658.8
    Conserved Domains (1) summary
    pfam00992
    Location:76211
    Troponin
  2. NM_001163665.1NP_001157137.1  troponin T, fast skeletal muscle isoform 2

    See identical proteins and their annotated locations for NP_001157137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (2) is the same size but has an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AI037743, AI173874, AI574395, CB196352, DV049834
    Consensus CDS
    CCDS52451.1
    UniProtKB/TrEMBL
    A0A0R4J1B0, J3QP61
    Related
    ENSMUSP00000101578.4, ENSMUST00000105958.10
    Conserved Domains (1) summary
    pfam00992
    Location:76211
    Troponin
  3. NM_001163666.1NP_001157138.1  troponin T, fast skeletal muscle isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI037743, AI746973, CK791812, DV049834
    Consensus CDS
    CCDS52456.1
    UniProtKB/TrEMBL
    Z4YKG8, Z4YKH8
    Related
    ENSMUSP00000101574.4, ENSMUST00000105954.10
    Conserved Domains (1) summary
    pfam00992
    Location:67202
    Troponin
  4. NM_001163667.1NP_001157139.1  troponin T, fast skeletal muscle isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI037743, BY766323, CK791812, DV049834
    Consensus CDS
    CCDS52454.1
    UniProtKB/Swiss-Prot
    A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
    UniProtKB/TrEMBL
    Z4YJU0
    Related
    ENSMUSP00000077587.9, ENSMUST00000078497.15
    Conserved Domains (1) summary
    pfam00992
    Location:72207
    Troponin
  5. NM_001163668.1NP_001157140.1  troponin T, fast skeletal muscle isoform 6

    See identical proteins and their annotated locations for NP_001157140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA771596, AI037743, CK791812, DV049834, U77779
    Consensus CDS
    CCDS52455.1
    UniProtKB/TrEMBL
    A2A6H6, Z4YKH8
    Related
    ENSMUSP00000101575.2, ENSMUST00000105955.8
    Conserved Domains (1) summary
    pfam00992
    Location:59195
    Troponin
  6. NM_001163669.1NP_001157141.1  troponin T, fast skeletal muscle isoform 5

    See identical proteins and their annotated locations for NP_001157141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA028290, AI037743, CK791812, DV049834
    Consensus CDS
    CCDS52453.1
    UniProtKB/TrEMBL
    Z4YKF8, Z4YKH8
    Related
    ENSMUSP00000101572.4, ENSMUST00000105952.10
    Conserved Domains (1) summary
    pfam00992
    Location:63199
    Troponin
  7. NM_001163670.1NP_001157142.1  troponin T, fast skeletal muscle isoform 8

    See identical proteins and their annotated locations for NP_001157142.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks four alternate in-frame exons compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA754928, AI037743, AK003147, DV049834
    Consensus CDS
    CCDS52457.1
    UniProtKB/TrEMBL
    A2A6J0, Z4YKH8
    Related
    ENSMUSP00000101569.2, ENSMUST00000105949.8
    Conserved Domains (1) summary
    pfam00992
    Location:48184
    Troponin
  8. NM_001347546.1NP_001334475.1  troponin T, fast skeletal muscle isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85475.1
    UniProtKB/TrEMBL
    Z4YKE7, Z4YKG3
    Related
    ENSMUSP00000101573.4, ENSMUST00000105953.10
    Conserved Domains (1) summary
    pfam00992
    Location:66201
    Troponin
  9. NM_001347547.1NP_001334476.1  troponin T, fast skeletal muscle isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85471.1
    UniProtKB/TrEMBL
    A0A0R4J1A8, Z4YKH8
    Related
    ENSMUSP00000127854.3, ENSMUST00000169299.9
    Conserved Domains (1) summary
    pfam00992
    Location:58194
    Troponin
  10. NM_001347548.1NP_001334477.1  troponin T, fast skeletal muscle isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85473.1
    UniProtKB/TrEMBL
    A2A6J1, Z4YKH8
    Related
    ENSMUSP00000101564.2, ENSMUST00000105944.3
    Conserved Domains (1) summary
    pfam00992
    Location:54190
    Troponin
  11. NM_001347549.1NP_001334478.1  troponin T, fast skeletal muscle isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (12) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85472.1
    UniProtKB/TrEMBL
    A2A6I0, Z4YKH8
    Related
    ENSMUSP00000101568.2, ENSMUST00000105948.8
    Conserved Domains (1) summary
    pfam00992
    Location:54190
    Troponin
  12. NM_001347550.1NP_001334479.1  troponin T, fast skeletal muscle isoform 13

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (13) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85474.1
    UniProtKB/TrEMBL
    A2A6I3, Z4YKH8
    Related
    ENSMUSP00000101561.2, ENSMUST00000105941.8
    Conserved Domains (1) summary
    pfam00992
    Location:52188
    Troponin
  13. NM_001347551.1NP_001334480.1  troponin T, fast skeletal muscle isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks five alternate in-frame exons compared to variant 1. The resulting isoform (14) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85477.1
    UniProtKB/TrEMBL
    A2A6I8, Z4YKH8
    Related
    ENSMUSP00000101562.2, ENSMUST00000105942.8
    Conserved Domains (1) summary
    pfam00992
    Location:43178
    Troponin
  14. NM_001347552.1NP_001334481.1  troponin T, fast skeletal muscle isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) lacks six alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (15) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS85476.1
    UniProtKB/TrEMBL
    A2A6I5, Z4YKH8
    Related
    ENSMUSP00000101563.2, ENSMUST00000105943.8
    Conserved Domains (1) summary
    pfam00992
    Location:43178
    Troponin
  15. NM_001360157.1NP_001347086.1  troponin T, fast skeletal muscle isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (16) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:61196
    Troponin
  16. NM_001360158.1NP_001347087.1  troponin T, fast skeletal muscle isoform 17

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (17) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:59195
    Troponin
  17. NM_011620.3NP_035750.2  troponin T, fast skeletal muscle isoform 7

    See identical proteins and their annotated locations for NP_035750.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI037743, AI322331, DV049834, U77779
    Consensus CDS
    CCDS22031.1
    UniProtKB/TrEMBL
    A0A0R4J1B1, Z4YKH8
    Related
    ENSMUSP00000073815.7, ENSMUST00000074187.13
    Conserved Domains (1) summary
    pfam00992
    Location:52188
    Troponin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142052530..142069746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508584.2XP_006508647.1  troponin T, fast skeletal muscle isoform X5

    See identical proteins and their annotated locations for XP_006508647.1

    UniProtKB/TrEMBL
    Z4YKD9, Z4YKH8
    Related
    ENSMUSP00000101567.2, ENSMUST00000105947.8
    Conserved Domains (1) summary
    pfam00992
    Location:63199
    Troponin
  2. XM_006508588.2XP_006508651.1  troponin T, fast skeletal muscle isoform X10

    See identical proteins and their annotated locations for XP_006508651.1

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:58194
    Troponin
  3. XM_036152902.1XP_036008795.1  troponin T, fast skeletal muscle isoform X8

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:58194
    Troponin
  4. XM_036152896.1XP_036008789.1  troponin T, fast skeletal muscle isoform X1

    UniProtKB/Swiss-Prot
    A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
    Conserved Domains (1) summary
    pfam00992
    Location:71207
    Troponin
  5. XM_036152903.1XP_036008796.1  troponin T, fast skeletal muscle isoform X9

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:58194
    Troponin
  6. XM_036152904.1XP_036008797.1  troponin T, fast skeletal muscle isoform X13

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:53189
    Troponin
  7. XM_036152905.1XP_036008798.1  troponin T, fast skeletal muscle isoform X14

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:53189
    Troponin
  8. XM_036152908.1XP_036008801.1  troponin T, fast skeletal muscle isoform X17

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:49185
    Troponin
  9. XM_036152898.1XP_036008791.1  troponin T, fast skeletal muscle isoform X3

    UniProtKB/Swiss-Prot
    A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
    Conserved Domains (1) summary
    pfam00992
    Location:70206
    Troponin
  10. XM_036152901.1XP_036008794.1  troponin T, fast skeletal muscle isoform X7

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:61197
    Troponin
  11. XM_036152909.1XP_036008802.1  troponin T, fast skeletal muscle isoform X18

    UniProtKB/TrEMBL
    Z4YKH8
    Related
    ENSMUSP00000116087.2, ENSMUST00000146804.8
    Conserved Domains (1) summary
    pfam00992
    Location:48184
    Troponin
  12. XM_036152897.1XP_036008790.1  troponin T, fast skeletal muscle isoform X2

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:70206
    Troponin
  13. XM_006508591.2XP_006508654.1  troponin T, fast skeletal muscle isoform X12

    See identical proteins and their annotated locations for XP_006508654.1

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:57193
    Troponin
  14. XM_006508590.2XP_006508653.1  troponin T, fast skeletal muscle isoform X11

    See identical proteins and their annotated locations for XP_006508653.1

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:57193
    Troponin
  15. XM_036152906.1XP_036008799.1  troponin T, fast skeletal muscle isoform X15

    UniProtKB/TrEMBL
    A0A0R4J1B1, Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:52188
    Troponin
  16. XM_036152899.1XP_036008792.1  troponin T, fast skeletal muscle isoform X4

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:65201
    Troponin
  17. XM_036152907.1XP_036008800.1  troponin T, fast skeletal muscle isoform X16

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:52188
    Troponin
  18. XM_036152911.1XP_036008804.1  troponin T, fast skeletal muscle isoform X20

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:47183
    Troponin
  19. XM_036152910.1XP_036008803.1  troponin T, fast skeletal muscle isoform X19

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:47183
    Troponin
  20. XM_036152900.1XP_036008793.1  troponin T, fast skeletal muscle isoform X6

    UniProtKB/TrEMBL
    Z4YKH8
    Conserved Domains (1) summary
    pfam00992
    Location:61197
    Troponin