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Tnni3 troponin I, cardiac 3 [ Mus musculus (house mouse) ]

Gene ID: 21954, updated on 5-Jan-2023

Summary

Official Symbol
Tnni3provided by MGI
Official Full Name
troponin I, cardiac 3provided by MGI
Primary source
MGI:MGI:98783
See related
Ensembl:ENSMUSG00000035458 AllianceGenome:MGI:98783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tn1; cTnI
Summary
Predicted to enable several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Acts upstream of or within several processes, including cellular calcium ion homeostasis; circulatory system development; and regulation of systemic arterial blood pressure by ischemic conditions. Located in sarcomere. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Used to study hypertrophic cardiomyopathy 7 and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 2467.4) See more
Orthologs
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Genomic context

See Tnni3 in Genome Data Viewer
Location:
7 A1; 7 2.61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4521304..4526228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4518305..4522718, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene troponin T1, skeletal, slow Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene synaptotagmin V Neighboring gene protein tyrosine phosphatase, receptor type, H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin C binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin T binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in heart contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by ischemic conditions IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within striated muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of cardiac Troponin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cardiac myofibril ISO
Inferred from Sequence Orthology
more info
 
located_in contractile fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin I, cardiac muscle
Names
cardiac troponin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009406.4NP_033432.1  troponin I, cardiac muscle

    See identical proteins and their annotated locations for NP_033432.1

    Status: VALIDATED

    Source sequence(s)
    AI843419, BC061171, BY115313
    Consensus CDS
    CCDS39736.1
    UniProtKB/Swiss-Prot
    P48787
    UniProtKB/TrEMBL
    A0A6P5PXA7, Q497F1
    Related
    ENSMUSP00000096458.4, ENSMUST00000098859.10
    Conserved Domains (2) summary
    pfam00992
    Location:47178
    Troponin; Troponin
    pfam11636
    Location:132
    Troponin-I_N; Troponin I residues 1-32

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4521304..4526228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322110.2XP_017177599.1  troponin I, cardiac muscle isoform X1

    Conserved Domains (2) summary
    pfam00992
    Location:55186
    Troponin
    pfam11636
    Location:140
    Troponin-I_N; Troponin I residues 1-32