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Tnni2 troponin I, skeletal, fast 2 [ Mus musculus (house mouse) ]

Gene ID: 21953, updated on 5-Mar-2024

Summary

Official Symbol
Tnni2provided by MGI
Official Full Name
troponin I, skeletal, fast 2provided by MGI
Primary source
MGI:MGI:105070
See related
Ensembl:ENSMUSG00000031097 AllianceGenome:MGI:105070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable troponin T binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated; regulation of muscle contraction; and striated muscle contraction. Predicted to be located in nucleus. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; diaphragm; eyelid epithelium; hindlimb muscle; and integumental system. Used to study distal arthrogryposis. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita and distal arthrogryposis type 2B1. Orthologous to human TNNI2 (troponin I2, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 95.5), lung adult (RPKM 12.7) and 4 other tissues See more
Orthologs
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Genomic context

See Tnni2 in Genome Data Viewer
Location:
7 F5; 7 87.93 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141995553..141998147)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142441816..142444410)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26143 Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene synaptotagmin VIII Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33 Neighboring gene troponin T3, skeletal, fast

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to actin binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin T binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin I, fast skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009405.3NP_033431.1  troponin I, fast skeletal muscle

    See identical proteins and their annotated locations for NP_033431.1

    Status: VALIDATED

    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS40192.1
    UniProtKB/Swiss-Prot
    A2A6J9, P13412
    UniProtKB/TrEMBL
    A0A1B0GRY8
    Related
    ENSMUSP00000101591.2, ENSMUST00000105971.8
    Conserved Domains (1) summary
    pfam00992
    Location:15145
    Troponin; Troponin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141995553..141998147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)