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OR8K3 olfactory receptor family 8 subfamily K member 3 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 219473, updated on 11-Jun-2021

Summary

Official Symbol
OR8K3provided by HGNC
Official Full Name
olfactory receptor family 8 subfamily K member 3 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:15313
See related
Ensembl:ENSG00000280314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-181
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Orthologs
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Genomic context

See OR8K3 in Genome Data Viewer
Location:
11q12.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (56315144..56320639)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (56085783..56086721)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily H member 1 Neighboring gene olfactory receptor family 8 subfamily I member 1 pseudogene Neighboring gene family with sequence similarity 8 member A2, pseudogene Neighboring gene olfactory receptor family 8 subfamily K member 2 pseudogene

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 8K3
Names
olfactory receptor OR11-181
olfactory receptor, family 8, subfamily K, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053137.1 RefSeqGene

    Range
    5001..5939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005202.2NP_001005202.1  olfactory receptor 8K3

    See identical proteins and their annotated locations for NP_001005202.1

    Status: VALIDATED

    Source sequence(s)
    AC022882
    UniProtKB/Swiss-Prot
    Q8NH51
    Related
    ENSP00000493271.1, ENST00000641662.1
    Conserved Domains (2) summary
    pfam00001
    Location:41289
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31302
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    56315144..56320639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871073.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    125893..131388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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