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Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus (house mouse) ]

Gene ID: 21942, updated on 5-Aug-2018
Official Symbol
Tnfrsf9provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 9provided by MGI
Primary source
MGI:MGI:1101059
See related
Ensembl:ENSMUSG00000028965 Vega:OTTMUSG00000010241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
Expression
Restricted expression toward placenta adult (RPKM 139.4) See more
Orthologs
See Tnfrsf9 in Genome Data Viewer
Location:
4 E2; 4 81.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (150920155..150946104)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150294264..150320211)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene predicted gene, 30120 Neighboring gene period circadian clock 3 Neighboring gene urotensin 2

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-12 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tumor necrosis factor receptor superfamily member 9
Names
4-1BB ligand receptor
CD137 antigen
T-cell antigen 4-1BB
secreted CD137 antigen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077508.1NP_001070976.1  tumor necrosis factor receptor superfamily member 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is a soluble form that lacks the transmembrane domain.
    Source sequence(s)
    AK019885, BC028507, BY206772, BY539760
    Consensus CDS
    CCDS38980.1
    UniProtKB/TrEMBL
    Q8R037
    Related
    ENSMUSP00000101297.3, ENSMUST00000105672.9
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
  2. NM_001077509.1NP_001070977.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001070977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK019885, BY196142, BY539760
    Consensus CDS
    CCDS18976.1
    UniProtKB/Swiss-Prot
    P20334
    UniProtKB/TrEMBL
    Q3U3R1
    Related
    ENSMUSP00000111961.1, ENSMUST00000116257.7
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
  3. NM_011612.2NP_035742.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK019885, BY206772, BY539760
    Consensus CDS
    CCDS18976.1
    UniProtKB/Swiss-Prot
    P20334
    UniProtKB/TrEMBL
    Q3U3R1
    Related
    ENSMUSP00000030808.3, OTTMUSP00000010903, ENSMUST00000030808.9, OTTMUST00000023800
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    150920155..150946104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250228.2XP_011248530.1  tumor necrosis factor receptor superfamily member 9 isoform X1

    See identical proteins and their annotated locations for XP_011248530.1

    UniProtKB/Swiss-Prot
    P20334
    UniProtKB/TrEMBL
    Q3U3R1
    Related
    ENSMUSP00000101296.1, OTTMUSP00000010904, ENSMUST00000105671.7, OTTMUST00000023801
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187025.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    1225243..1251241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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