U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus (house mouse) ]

Gene ID: 21942, updated on 12-May-2024

Summary

Official Symbol
Tnfrsf9provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 9provided by MGI
Primary source
MGI:MGI:1101059
See related
Ensembl:ENSMUSG00000028965 AllianceGenome:MGI:1101059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ILA; Ly63; 4-1BB; Cd137; CDw137; A930040I11Rik
Summary
Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 139.4) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tnfrsf9 in Genome Data Viewer
Location:
4 E2; 4 81.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (151004612..151030561)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150920155..150946104)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene STARR-positive B cell enhancer ABC_E10293 Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:150271076-150271277 Neighboring gene STARR-seq mESC enhancer starr_12178 Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene STARR-positive B cell enhancer ABC_E2733 Neighboring gene STARR-positive B cell enhancer ABC_E6289 Neighboring gene predicted gene, 23405 Neighboring gene predicted gene, 30120

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 9
Names
4-1BB ligand receptor
CD137 antigen
T-cell antigen 4-1BB
secreted CD137 antigen

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077508.1NP_001070976.1  tumor necrosis factor receptor superfamily member 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is a soluble form that lacks the transmembrane domain.
    Source sequence(s)
    AK019885, BC028507, BY206772, BY539760
    Consensus CDS
    CCDS38980.1
    UniProtKB/TrEMBL
    A2A887, Q8R037
    Related
    ENSMUSP00000101297.4, ENSMUST00000105672.10
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
  2. NM_001077509.1NP_001070977.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001070977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK019885, BY196142, BY539760
    Consensus CDS
    CCDS18976.1
    UniProtKB/Swiss-Prot
    P20334
    UniProtKB/TrEMBL
    A2A888, Q3U3R1
    Related
    ENSMUSP00000111961.2, ENSMUST00000116257.8
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
  3. NM_011612.2NP_035742.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK019885, BY206772, BY539760
    Consensus CDS
    CCDS18976.1
    UniProtKB/Swiss-Prot
    P20334
    UniProtKB/TrEMBL
    A2A888, Q3U3R1
    Related
    ENSMUSP00000030808.4, ENSMUST00000030808.10
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    151004612..151030561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250228.3XP_011248530.1  tumor necrosis factor receptor superfamily member 9 isoform X1

    See identical proteins and their annotated locations for XP_011248530.1

    UniProtKB/Swiss-Prot
    P20334
    UniProtKB/TrEMBL
    A2A888, Q3U3R1
    Related
    ENSMUSP00000101296.2, ENSMUST00000105671.8
    Conserved Domains (1) summary
    cd13410
    Location:23160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137