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Cenpj centromere protein J [ Mus musculus (house mouse) ]

Gene ID: 219103, updated on 5-Mar-2024

Summary

Official Symbol
Cenpjprovided by MGI
Official Full Name
centromere protein Jprovided by MGI
Primary source
MGI:MGI:2684927
See related
Ensembl:ENSMUSG00000064128 AllianceGenome:MGI:2684927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAP; CPAP; Gm81; LIP1; Sas4; 4932437H03Rik
Summary
Predicted to enable several functions, including gamma-tubulin binding activity; identical protein binding activity; and transcription coactivator activity. Acts upstream of or within organelle assembly; positive regulation of non-motile cilium assembly; and smoothened signaling pathway. Located in centriole and ciliary basal body. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and vibrissa. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 4; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 6. Orthologous to human CENPJ (centromere protein J). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.6), CNS E14 (RPKM 2.2) and 18 other tissues See more
Orthologs
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Genomic context

See Cenpj in Genome Data Viewer
Location:
14 C3; 14 28.28 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56764218..56812950, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56526761..56575489, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 17 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene predicted gene, 50496 Neighboring gene predicted gene, 24392 Neighboring gene STARR-seq mESC enhancer starr_36796 Neighboring gene STARR-positive B cell enhancer ABC_E10828 Neighboring gene STARR-positive B cell enhancer ABC_E5442 Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573 Neighboring gene basic transcription factor 3, pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102215

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within astral microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within centriole assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centriole elongation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of centriole elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of spindle assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle organization NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centromere protein J
Names
CENP-J

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014996.3NP_001014996.2  centromere protein J isoform 1

    See identical proteins and their annotated locations for NP_001014996.2

    Status: VALIDATED

    Source sequence(s)
    AC154837
    Consensus CDS
    CCDS27150.1
    UniProtKB/Swiss-Prot
    E9QLP3, Q569L8
    Related
    ENSMUSP00000065949.8, ENSMUST00000065302.8
    Conserved Domains (2) summary
    TIGR02169
    Location:9051060
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam07202
    Location:11581186
    Tcp10_C; T-complex protein 10 C-terminus
  2. NM_001403533.1NP_001390462.1  centromere protein J isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154837
  3. NM_001403534.1NP_001390463.1  centromere protein J isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154837

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56764218..56812950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518849.4XP_006518912.1  centromere protein J isoform X1

    See identical proteins and their annotated locations for XP_006518912.1

    Conserved Domains (4) summary
    TIGR02168
    Location:8751039
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07202
    Location:11601335
    Tcp10_C; T-complex protein 10 C-terminus
    pfam07426
    Location:121183
    Dynactin_p22; Dynactin subunit p22
    pfam11819
    Location:303390
    DUF3338; Domain of unknown function (DUF3338)