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Timp3 tissue inhibitor of metalloproteinase 3 [ Mus musculus (house mouse) ]

Gene ID: 21859, updated on 16-Apr-2024


Official Symbol
Timp3provided by MGI
Official Full Name
tissue inhibitor of metalloproteinase 3provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000020044 AllianceGenome:MGI:98754
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of metalloendopeptidase activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]
Biased expression in kidney adult (RPKM 234.0), lung adult (RPKM 92.0) and 12 other tissues See more
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Genomic context

10 C1; 10 42.83 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86136276..86185369)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86300412..86349505)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930486F22 gene Neighboring gene synapsin III Neighboring gene STARR-seq mESC enhancer starr_27457 Neighboring gene STARR-seq mESC enhancer starr_27458 Neighboring gene predicted gene, 35636 Neighboring gene STARR-seq mESC enhancer starr_27459 Neighboring gene VISTA enhancer mm52 Neighboring gene predicted gene, 57766 Neighboring gene STARR-seq mESC enhancer starr_27465 Neighboring gene predicted gene 6729 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
metalloproteinase inhibitor 3
tissue inhibitor of metalloproteinases 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011595.2NP_035725.1  metalloproteinase inhibitor 3 precursor

    See identical proteins and their annotated locations for NP_035725.1

    Status: VALIDATED

    Source sequence(s)
    AK083905, AK147847, BE651900, BY439696
    Consensus CDS
    P39876, Q91WL9
    ENSMUSP00000020234.8, ENSMUST00000020234.14
    Conserved Domains (1) summary
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000076.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)