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Timeless timeless circadian clock 1 [ Mus musculus (house mouse) ]

Gene ID: 21853, updated on 14-Nov-2019

Summary

Official Symbol
Timelessprovided by MGI
Official Full Name
timeless circadian clock 1provided by MGI
Primary source
MGI:MGI:1321393
See related
Ensembl:ENSMUSG00000039994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tim; C77407; Debt69
Summary
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Broad expression in CNS E11.5 (RPKM 6.3), limb E14.5 (RPKM 3.8) and 24 other tissues See more
Orthologs

Genomic context

See Timeless in Genome Data Viewer
Location:
10 D3; 10 76.49 cM
Exon count:
31
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128232063..128252941)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127669119..127689997)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutaminase 2 (liver, mitochondrial) Neighboring gene SPRY domain containing 4 Neighboring gene predicted gene, 26847 Neighboring gene major intrinsic protein of lens fiber Neighboring gene apolipoprotein N Neighboring gene apolipoprotein F Neighboring gene signal transducer and activator of transcription 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to bleomycin ISO
Inferred from Sequence Orthology
more info
 
cellular response to cisplatin ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of an epithelium IEP
Inferred from Expression Pattern
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork protection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein timeless homolog
Names
mTim
timeless homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136082.2NP_001129554.1  protein timeless homolog isoform 1

    See identical proteins and their annotated locations for NP_001129554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. This variant is distinct from but the same length as variant 3. The resulting isoform (1) lacks one aa near the C-terminus, compared to isoform 2, and is distinct from isoform 3.
    Source sequence(s)
    BC052884, BC082770
    Consensus CDS
    CCDS48725.1
    UniProtKB/Swiss-Prot
    Q9R1X4
    Related
    ENSMUSP00000100876.1, ENSMUST00000105242.7
    Conserved Domains (3) summary
    pfam05029
    Location:7221189
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25284
    TIMELESS; Timeless protein
    cl10555
    Location:539611
    Chorismate_bind; chorismate binding enzyme
  2. NM_001164080.1NP_001157552.1  protein timeless homolog isoform 3

    See identical proteins and their annotated locations for NP_001157552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The resulting isoform (3) lacks one aa near the C-terminus, compared to isoform 2.
    Source sequence(s)
    AK153838, BC052884, BC082770
    Consensus CDS
    CCDS48724.1
    UniProtKB/Swiss-Prot
    Q9R1X4
    UniProtKB/TrEMBL
    Q3U574
    Related
    ENSMUSP00000100878.1, ENSMUST00000105244.7
    Conserved Domains (3) summary
    pfam05029
    Location:7221189
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25284
    TIMELESS; Timeless protein
    cl10555
    Location:539611
    Chorismate_bind; chorismate binding enzyme
  3. NM_001164081.1NP_001157553.1  protein timeless homolog isoform 2

    See identical proteins and their annotated locations for NP_001157553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    BC052884, BC082770, CJ088470
    Consensus CDS
    CCDS24266.1
    UniProtKB/Swiss-Prot
    Q9R1X4
    Related
    ENSMUSP00000058021.4, ENSMUST00000055539.10
    Conserved Domains (3) summary
    pfam05029
    Location:7221190
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25284
    TIMELESS; Timeless protein
    cl10555
    Location:539611
    Chorismate_bind; chorismate binding enzyme
  4. NM_011589.2NP_035719.1  protein timeless homolog isoform 2

    See identical proteins and their annotated locations for NP_035719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 4. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AF098161, BC082770
    Consensus CDS
    CCDS24266.1
    UniProtKB/Swiss-Prot
    Q9R1X4
    Related
    ENSMUSP00000100879.2, ENSMUST00000105245.2
    Conserved Domains (3) summary
    pfam05029
    Location:7221190
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25284
    TIMELESS; Timeless protein
    cl10555
    Location:539611
    Chorismate_bind; chorismate binding enzyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    128232063..128252941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245050.1XP_030100910.1  protein timeless homolog isoform X6

  2. XM_030245049.1XP_030100909.1  protein timeless homolog isoform X4

  3. XM_006513582.2XP_006513645.1  protein timeless homolog isoform X3

    Conserved Domains (3) summary
    pfam05029
    Location:7831250
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:86345
    TIMELESS; Timeless protein
    cl10555
    Location:600672
    Chorismate_bind; chorismate binding enzyme
  4. XM_006513581.4XP_006513644.1  protein timeless homolog isoform X2

    Conserved Domains (3) summary
    pfam05029
    Location:7831250
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:86345
    TIMELESS; Timeless protein
    cl10555
    Location:600672
    Chorismate_bind; chorismate binding enzyme
  5. XM_006513580.2XP_006513643.1  protein timeless homolog isoform X1

    Conserved Domains (3) summary
    pfam05029
    Location:7831251
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:86345
    TIMELESS; Timeless protein
    cl10555
    Location:600672
    Chorismate_bind; chorismate binding enzyme
  6. XM_006513583.3XP_006513646.1  protein timeless homolog isoform X5

    See identical proteins and their annotated locations for XP_006513646.1

    UniProtKB/Swiss-Prot
    Q9R1X4
    Conserved Domains (3) summary
    pfam05029
    Location:7221190
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25284
    TIMELESS; Timeless protein
    cl10555
    Location:539611
    Chorismate_bind; chorismate binding enzyme
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