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B4galt7 xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) [ Mus musculus (house mouse) ]

Gene ID: 218271, updated on 8-Dec-2022

Summary

Official Symbol
B4galt7provided by MGI
Official Full Name
xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)provided by MGI
Primary source
MGI:MGI:2384987
See related
Ensembl:ENSMUSG00000021504 AllianceGenome:MGI:2384987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XGPT; XGalT-1
Summary
Predicted to enable beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; manganese ion binding activity; and xylosylprotein 4-beta-galactosyltransferase activity. Predicted to be involved in several processes, including glycoprotein biosynthetic process; glycosaminoglycan biosynthetic process; and negative regulation of fibroblast proliferation. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 11.8), limb E14.5 (RPKM 11.7) and 28 other tissues See more
Orthologs
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Genomic context

See B4galt7 in Genome Data Viewer
Location:
13; 13 B1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55747709..55758258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55599896..55610443)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31364 Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene calcium modulating ligand Neighboring gene DEAD box helicase 46

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC28643

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables xylosylprotein 4-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables xylosylprotein 4-beta-galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xylosylprotein 4-beta-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycosaminoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
beta-1,4-galactosyltransferase 7
Names
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7
UDP-galactose:beta-xylose beta-1,4-galactosyltransferase
b4Gal-T7
beta-1,4-GalTase 7
beta4Gal-T7
proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I
xylosylprotein 4-beta-galactosyltransferase
xylosylprotein beta-1,4-galactosyltransferase
NP_001298066.1
NP_666157.1
XP_036013888.1
XP_036013889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311137.1NP_001298066.1  beta-1,4-galactosyltransferase 7 isoform 2

    See identical proteins and their annotated locations for NP_001298066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    BC055703, BF455923
    Consensus CDS
    CCDS79190.1
    UniProtKB/Swiss-Prot
    Q8R087
    UniProtKB/TrEMBL
    A0A8C6HID6
    Related
    ENSMUSP00000098327.4, ENSMUST00000100764.10
    Conserved Domains (1) summary
    cd00899
    Location:92280
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. NM_146045.2NP_666157.1  beta-1,4-galactosyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_666157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146855, BC055703, BF455923
    Consensus CDS
    CCDS26550.1
    UniProtKB/Swiss-Prot
    Q7TNU3, Q8R087
    UniProtKB/TrEMBL
    A0A8C6HKF9, Q3TAW1
    Related
    ENSMUSP00000068532.7, ENSMUST00000064701.8
    Conserved Domains (1) summary
    cd00899
    Location:92315
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55747709..55758258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157995.1XP_036013888.1  beta-1,4-galactosyltransferase 7 isoform X1

    Related
    ENSMUSP00000123292.2, ENSMUST00000133176.8
    Conserved Domains (1) summary
    cd00899
    Location:36259
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. XM_036157996.1XP_036013889.1  beta-1,4-galactosyltransferase 7 isoform X2

    Conserved Domains (1) summary
    cd00899
    Location:36224
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids