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B4galt7 beta-1,4-galactosyltransferase 7 [ Mus musculus (house mouse) ]

Gene ID: 218271, updated on 2-Nov-2024

Summary

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Official Symbol
B4galt7provided by MGI
Official Full Name
beta-1,4-galactosyltransferase 7provided by MGI
Primary source
MGI:MGI:2384987
See related
Ensembl:ENSMUSG00000021504 AllianceGenome:MGI:2384987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XGPT; XGalT-1
Summary
Enables xylosylprotein 4-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 11.8), limb E14.5 (RPKM 11.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See B4galt7 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55747709..55758258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55599896..55610443)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31364 Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene calcium modulating ligand Neighboring gene DEAD box helicase 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A quantitative study of the Golgi retention of glycosyltransferases. Sun X, et al. J Cell Sci, 2021 Oct 15. PMID 34533190
  2. Biochemical and thermodynamic characterization of mutated β1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome. Rahuel-Clermont S, et al. Biochem J, 2010 Dec 1. PMID 20809901
  3. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Ma H, et al. Nature, 2020 Dec. PMID 33208938, Free PMC Article
  4. Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I. de la Cruz L, et al. Dev Biol, 2004 Aug 15. PMID 15282149
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. surface GalT I might negatively regulate mammary epithelial cell survival
    Title: Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC28643

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables xylosylprotein 4-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xylosylprotein 4-beta-galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables xylosylprotein 4-beta-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables xylosylprotein 4-beta-galactosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosaminoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
  
involved_in supramolecular fiber organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 7
Names
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7
UDP-galactose:beta-xylose beta-1,4-galactosyltransferase
b4Gal-T7
beta-1,4-GalTase 7
beta4Gal-T7
proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I
xylosylprotein 4-beta-galactosyltransferase
xylosylprotein beta-1,4-galactosyltransferase
xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
NP_001298066.1
NP_666157.1
XP_036013888.1
XP_036013889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311137.1 → NP_001298066.1  beta-1,4-galactosyltransferase 7 isoform 2

    See identical proteins and their annotated locations for NP_001298066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    BC055703, BF455923
    Consensus CDS
    CCDS79190.1
    UniProtKB/TrEMBL
    Q3UR73
    Related
    ENSMUSP00000098327.4, ENSMUST00000100764.10
    Conserved Domains (1) summary
    cd00899
    Location:92 → 280
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. NM_146045.2 → NP_666157.1  beta-1,4-galactosyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_666157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146855, BC055703, BF455923
    Consensus CDS
    CCDS26550.1
    UniProtKB/Swiss-Prot
    Q7TNU3, Q8R087
    UniProtKB/TrEMBL
    Q3TAW1, Q3UR73
    Related
    ENSMUSP00000068532.7, ENSMUST00000064701.8
    Conserved Domains (1) summary
    cd00899
    Location:92 → 315
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55747709..55758258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157995.1 → XP_036013888.1  beta-1,4-galactosyltransferase 7 isoform X1

    UniProtKB/TrEMBL
    Q3UR73
    Related
    ENSMUSP00000123292.2, ENSMUST00000133176.8
    Conserved Domains (1) summary
    cd00899
    Location:36 → 259
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. XM_036157996.1 → XP_036013889.1  beta-1,4-galactosyltransferase 7 isoform X2

    UniProtKB/TrEMBL
    D3Z065
    Conserved Domains (1) summary
    cd00899
    Location:36 → 224
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R087.1 GenPept UniProtKB/Swiss-Prot:Q8R087

Gene LinkOut

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